書誌事項
- タイトル別名
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- Double minute chromosomes(DMs) in a case of acute myelomonocytic leukemia.
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抄録
A 71-year old male was admitted to our hospital because of general malaise and fever. Peripheral blood showed Hb 8.1 g/dl, platelet 7.0×104/μl, and WBC 18.100/μl with 64% leukemic cells. Bone marrow showed normocellularity with 73.4% leukemic cells. They were positive for peroxidase and α-naphthyl butyrate esterase stainings. Serum and urine lysozyme levels were elevated. He was diagnosed as having acute myelomocytic leukemia (M 4 in FAB classification). Chromosome analysis of bone marrow cells showed 45, XY, -17, t(9;17) (q22;p13) and double minute chromosomes (DMs) were observed in the 50 cells analyzed.<br>A complete remission (CR) was obtained by DCMP regimen, but he relapsed as acute monocytic leukemia (M 5 b in FAB classification) and died 5 months after diagnosis. DMs apper to be rare in acute leukemia and the clinical and etiologic implications of DMs are discussed.
収録刊行物
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- 臨床血液
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臨床血液 30 (6), 882-886, 1989
一般社団法人 日本血液学会