Urinary Excretion of Parathyroid Hormone-Related Protein in Patients with Adult T-cell Leukemia and Other Hematologic Disorders

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  • MORI Naoki
    The First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine
  • OHSUMI Kazuoki
    Mitsubishi Yuka BCL
  • MURAKAMI Shuichi
    The First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine
  • WAKE Atsushi
    The First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine
  • NAKATA Koichi
    The First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine
  • MISAGO Masahiro
    The First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine
  • ODA Susumu
    The First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine
  • ETO Sumiya
    The First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine

Bibliographic Information

Other Title
  • 成人T細胞白血病および各種血液疾患における尿中副甲状腺ホルモン関連蛋白の排泄
  • セイジン Tサイボウ ハッケツビョウ オヨビ カクシュ ケツエキ シッカン ニ

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Abstract

Urinary excretion of parathyroid hormone-related protein (PTH-rP) was measured by radioimmunoassay in 25 patients with adult T-cell leukemia (ATL), in 68 patients with other hematologic disorders and in 13 asymptomatic individuals seropositive for human T-cell leukemia virus type I (HTLV-I). The mean levels of urinary PTH-rP in ATL patients with hypercalcemia (11.01 μg/g·Cr) were higher than in ATL patients with normocalcemia (5.16 μg/g·Cr). The mean levels in patients with acute type (8.84 μg/g·Cr), lymphoma type (4.18 μg/g·Cr) and crisis ATL (18.20 μg/g·Cr) were significantly higher than in urine of healthy controls. However, all asymptomatic carriers of HTLV-I and patients with chronic and smoldering ATL had normal urinay PTH-rP levels. In 7 patients with acute myelogenous leukemia, 1 patient with blastic crisis of chronic myelogenous leukemia and 3 patients with malignant lymphoma, the urinary levels of PTH-rP were above the normal range. Urinary levels of PTH-rP of the ATL patients with hypercalcemia correlated with the serum calcium levels. Urinary levels of PTH-rP of the all ATL correlated with serum lactic dehydrogenase level. These findings suggest that the measurement of urinary levels of PTH-rP is useful for evaluation of ATL and that some tumor cells of other hematologic diseases may produce PTH-rP.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 33 (9), 1158-1165, 1992

    The Japanese Society of Hematology

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