自己免疫性溶血性貧血におけるT細胞サブセットの検討  [in Japanese] Analysis of T Cell Subsets in Autoimmune Hemolytic Anemia Patients  [in Japanese]

Access this Article

Author(s)

Abstract

自己免疫性溶血性貧血(AIHA)における免疫調節性T細胞(IRT)などの病態への関与を知るため,AIHA患者15名の末梢血T細胞subsetを二重染色法を用いて解析した。その結果,活動期,寛解期を問わずAIHA患者ではCD4+細胞が減少しており,subsetとしてはCD4+CD45RA+細胞(naive T-cell)が減少していた。なおCD4+細胞中に占めるCD45RA+細胞の比率は活動期に低下していたが,寛解期には正常化した。また活動期患者ではCD8++細胞の増加を認め,subsetではCD8++S6F1+細胞(activated cytotoxic T lymphocyte; aCTL)が増加していた。しかし寛解期には両者共正常値を示した。以上よりAIHAの病態形成にはIRTの一つと思われるCD4+CD45RA+細胞の病的変動とさらにはaCTLの関与していることが示唆された。

To clarify a role of immunoregulatory T cells in the pathophysiology of autoimmune hemolytic anemia (AIHA), we investigated T cell subsets in the peripheral blood of 15 patients with AIHA by two color analysis using flow cytometry. Consequently both CD4+ cells and CD4+CD45RA+ cells decreased in proportion, irrespective of the disease activity (active or remission phase). CD4+CD45RA+ cells are regarded as naive T cells. Incidentally the ratio of CD45RA+ cells in CD4+ cells also fell in the low level in active phase, but it recovered to the normal ratio in remission. On the other hand, CD8+ cells and CD8++S6F1+ cells that may represent activated cytotoxic T lymphocytes increased in active phase and then both entered the normal range in remission. These findings suggest that AIHA could be caused partly by the alternative balance of CD4+CD45RA+cells probably constituting a member of IRT and moreover by the activation of CTL.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 36(1), 1-5, 1995

    The Japanese Society of Hematology

Codes

  • NII Article ID (NAID)
    130004500132
  • Text Lang
    JPN
  • ISSN
    0485-1439
  • Data Source
    J-STAGE 
Page Top