STIMULATORY CAPACITY OF AN OCTACALCIUM PHOSPHATE/GELATIN COMPOSITE ON BONE REGENERATION IN A RABBIT TIBIA DEFECT MODEL

• Suzuki Kentaro

  Department of Orthopaedic Surgery, Graduate School of Medicine, Tohoku University Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry

• Honda Yoshitomo

  Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry

• Anada Takahisa

  Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry

• Handa Takuto

  Shinoda General Hospital Division of Oral Surgery

• Miyatake Naohisa

  Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry Sendai Orthopaedic Hospital

• Takahashi Atsushi

  Department of Orthopaedic Surgery, Graduate School of Medicine, Tohoku University

• Hosaka Masami

  Department of Orthopaedic Surgery, Graduate School of Medicine, Tohoku University

• Imaizumi Hideki

  Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry Osaki Citizen Hospital

• Itoi Eiji

  Department of Orthopaedic Surgery, Graduate School of Medicine, Tohoku University

• Suzuki Osamu

  Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry

Bibliographic Information

Other Title

• Stimulatory capacity of an octacalcium phosphate/gelatin composite on bone regeneration
• Stimulatory capacity of an octacalcium phosphate/gelatin composite on bone regeneration in rabbit tibia defect model

Abstract

The present study was designed to investigate whether an octacalcium phosphate/gelatin (OCP/Gel) composite can repair a defect created in rabbit tibia within 4 weeks. Histological and μCT studies showed that the implantation of OCP/Gel composite (40 wt% OCP) enhances cortical bone deposition over the defect accompanied by the formation of cartilage and bone marrow with cancellous bone within 2 weeks. The defects were repaired even in the control group (defect only) within 4 weeks; however, the repaired cortical bone was thinner than that in the OCP/Gel-implanted group. The results suggest that an OCP/Gel composite could be effectively used as a bone substitute material for autografts.

Journal

• Phosphorus Research Bulletin

  Phosphorus Research Bulletin 26 (0), 53-58, 2012

  Japanese Association of Inorganic Phosphorus Chemistry

Keywords

• Octacalcium phosphate
• Gelatin
• Bone regeneration
• Long bone
• Tibia

Details

• CRID: 1390282680264178816
• NII Article ID: 130004502145
• DOI: 10.3363/prb.26.53
• COI: 1:CAS:528:DC%2BC38XhslKjt73M
• ISSN: 18822363
• ISSN: 09184783
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed