小児と成人におけるボリコナゾールの血中濃度解析の比較 [in Japanese] Comparison of Relationship between Dosage and Serum Concentration of Voriconazole in Adult and Pediatric Patients [in Japanese]
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The purpose of this study was to investigate whether the trough plasma concentration of voriconazole (VRCZ) in the steady-state (C<sub>min</sub>) influences efficacy and safety in adult and pediatric patients.<br>Treatment was successful in 75% of pediatric patients and 56% of adult patients,and there was no association between C<sub>min</sub> and efficacy.However,liver dysfunction occurred more frequently in the case that C<sub>min</sub> was over 4μg/mL in both adult and pediatric patients.Also,pediatric patients,especially those younger than 2 years,required a higher dose of VRCZ than adults to achieve a similar C<sub>min</sub>.<br>We concluded that the use of VRCZ at a constant dose over a long period may lead to an increase in C<sub>min</sub>.Therefore,careful,continuous monitoring of the C<sub>min</sub> of VRCZ is necessary for pediatric patients,particularly recipients of hematopoietic stem cell transplantation.
- Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)
Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) 36(4), 213-219, 2010
Japanese Society of Pharmaceutical Health Care and Sciences