小児と成人におけるボリコナゾールの血中濃度解析の比較  [in Japanese] Comparison of Relationship between Dosage and Serum Concentration of Voriconazole in Adult and Pediatric Patients  [in Japanese]

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Author(s)

    • 中尾 眞二 Nakao Shinji
    • 金沢大学細胞移植学 Department of Cellular Transplantation Biology, Kanazawa University School of Medicine
    • 石崎 純子 Ishizaki Junko
    • 金沢大学医薬保健研究域薬学系臨床薬物情報学 Department of Clinical Drug Informatics, Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University
    • 五十嵐 康郎 Igarashi Yasuro
    • 金沢大学医薬保健研究域薬学系臨床薬物情報学 Department of Clinical Drug Informatics, Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University
    • 菅 幸生 Suga Yukio
    • 金沢大学医薬保健研究域薬学系臨床薬物情報学 Department of Clinical Drug Informatics, Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University

Abstract

The purpose of this study was to investigate whether the trough plasma concentration of voriconazole (VRCZ) in the steady-state (C<sub>min</sub>) influences efficacy and safety in adult and pediatric patients.<br>Treatment was successful in 75% of pediatric patients and 56% of adult patients,and there was no association between C<sub>min</sub> and efficacy.However,liver dysfunction occurred more frequently in the case that C<sub>min</sub> was over 4μg/mL in both adult and pediatric patients.Also,pediatric patients,especially those younger than 2 years,required a higher dose of VRCZ than adults to achieve a similar C<sub>min</sub>.<br>We concluded that the use of VRCZ at a constant dose over a long period may lead to an increase in C<sub>min</sub>.Therefore,careful,continuous monitoring of the C<sub>min</sub> of VRCZ is necessary for pediatric patients,particularly recipients of hematopoietic stem cell transplantation.

Journal

  • Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)

    Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) 36(4), 213-219, 2010

    Japanese Society of Pharmaceutical Health Care and Sciences

Cited by:  1

Codes

  • NII Article ID (NAID)
    130004502587
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    1346-342X
  • Data Source
    CJPref  J-STAGE 
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