書誌事項
- タイトル別名
-
- Study on Standardized Use of Metronidazole against Clostridium difficile -associated Diarrhea
- Study on Standardized Use of Metronidazole against Clostridium difficile-associated Diarrhea: Creation of a flow chart to ensure proper use and its evaluation
- Creation of a flow chart to ensure proper use and its evaluation
- -フローチャートによる適正使用の試みと評価-
抄録
Metronidazole (MNZ),an inexpensive and highly active drug,is the first choice in many countries worldwide for eradicationof Clostridium difficile,which causes antibiotic-associated diarrhea (C.difficile-associated diarrhea or CDAD).However,MNZ has not been approved for the treatment of CDAD in Japan,and vancomycin (VCM) is often used instead.In recent years,there has been much concern regarding the spread of VCM-resistant bacteria,and careful use of VCM isnow advocated.In order to ensure the proper and consistent use of MNZ in the treatment of CDAD,we determined criteriafor drug selection,contraindications,dosage,administration,discontinuance,and modification.We also created a flow chartto simplify treatment.After the introduction of the flowchart,as a result of pharmacist intervention,the quantity of VCMused decreased from 78.4% to 35.1%,and the quantity of MNZ used increased from 21.6% to 64.9%.This reduced drugcosts by 37.4%.However,there was no significant difference between MNZ and VCM in terms of improvement of CDADand its rate of recurrence,and adverse effects due to MNZ caused were only mild.Our flow chart enabled appropriate drug selection for patients with CDAD as well as prompt determination of dosage andadministration details.Following its procedures should help standardize the use of MNZ.
収録刊行物
-
- 医療薬学
-
医療薬学 37 (2), 119-125, 2011
一般社団法人日本医療薬学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282679753701504
-
- NII論文ID
- 130004502664
-
- ISSN
- 18821499
- 1346342X
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可