Radiological Morphometric Analysis of the Mandibular Bone Structure after Ovariectomy in Mature Cynomolgus Monkeys

• Asai Hideomi

  Division of Radiology, Department of Maxillofacial Diagnostic Science, Kanagawa Dental College

• Kozai Yusuke

  Division of Radiology, Department of Maxillofacial Diagnostic Science, Kanagawa Dental College

• Matsumoto Yukiko

  Division of Radiology, Department of Maxillofacial Diagnostic Science, Kanagawa Dental College

• Kawamata Ryota

  Division of Radiology, Department of Maxillofacial Diagnostic Science, Kanagawa Dental College

• Kumasaka Satsuki

  Department of Radiological Sciences, Faculty of Health Sciences, Komazawa University

• Sakurai Takashi

  Division of Radiology, Department of Maxillofacial Diagnostic Science, Kanagawa Dental College

• Kashima Isamu

  Division of Radiology, Department of Maxillofacial Diagnostic Science, Kanagawa Dental College

Abstract

[Purpose] The effects of experimental osteoporosis on the trabecular bone structure of the mandible in cynomolgus monkeys were examined by radiological bone morphometric analysis. [Methods] Ovariectomy (OVX) was performed on twelve 10-year-old female cynomolgus monkeys, which were fed a controlled diet for 2 years. Twelve monkeys in a sham control group were fed under the same conditions. Using a microfocus tube and computed radiography, the removed mandibular bone samples were imaged by standardized magnification radiography, and two-dimensional digital imaging data were obtained. The structural parameters, such as skeletal area, perimeter, number, complexity, continuity and anisotropy, were measured using radiological bone morphometric analysis. The bone mineral density (BMD) was measured by dual energy X-ray absorptiometry. The width of the cortical bone was measured using magnified radiographic images. [Results] There were no significant differences between the OVX and the sham control groups in the skeletal structure indicated by the skeletal volume, number, width, perimeter, complexity, continuity, separation and spacing. However, there were significant differences between the two groups in the BMD of the mandibular body, cortical bone width, anisotropy and some parameters of the skeletal continuity. Among these parameters, the difference in the thinning of the cortical bone was most significant. [Conclusions] Using two-dimensional digital radiographic image data, this study suggests that the cortical bone width is more useful than the trabecular bone structure as the morphologic parameter for diagnosis of osteoporosis in the mandibular body.

Journal

• Oral Science International

  Oral Science International 2 (1), 54-63, 2005

  Japanese Stomatological Society

Keywords

• bone structure
• digital radiography
• mandibular bone
• bone morphometry
• cynomolgus monkey

Details

• CRID: 1390282680199429760
• NII Article ID: 130004503809
• NII Article ID: 50003902470
• DOI: 10.11277/osi.2.54
• ISSN: 18814204
• ISSN: 13488643
• Web Site: https://search.jamas.or.jp/link/ui/2006089016
• Text Lang: en
• Data Source:
  • JaLC
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed