Development of Chiral Screening Test Method of Methamphetamine and Its Metabolites in Urine by Capillary Electrophoresis

• Chinaka Satoshi

  Forensic Science Laboratory, Ishikawa Prefectural Police H.Q.

• Iio Reiko

  Forensic Science Laboratory, Ishikawa Prefectural Police H.Q.

• Tanaka Seishi

  Forensic Science Laboratory, Ishikawa Prefectural Police H.Q.

• Takayama Nariaki

  Forensic Science Laboratory, Ishikawa Prefectural Police H.Q.

• Hayakawa Kazuichi

  Graduate School of Natural Science and Technology, Kanazawa University

Bibliographic Information

Other Title

• キャピラリー電気泳動法による尿中覚せい剤およびその代謝物の光学異性体スクリーニング試験法の開発

Abstract

  A rapid and simple analysis method for the chiral determination of methamphetamine (MA) and its metabolites, amphetamine (AP) and p-hydroxymethamphetamine (pOHMA), in urine by capillary electrophoresis (CE) has been developed. Urine sample was directly injected into the CE system after pretreatment of dilution and filtration. In the analyses of healthy people's urine samples spiked with MA, AP and pOHMA, the detection limits in urine were 0.5, 0.5 and 0.3 μg/ml, respectively. The recovery of each compound from urine was 95-105%. The proposed method was successfully applicable to the chiral analysis of urine samples from MA addicts.<br>

Journal

• Japanese journal of science and technology for identification

  Japanese journal of science and technology for identification 9 (2), 103-111, 2004

  Japanese Association of Forensic Science and Technology

Keywords

• Methamphetamine
• Capillary Electrophoresis
• Chiral Analysis
• Direct Injection
• Urine

Details

• CRID: 1390001204482587008
• NII Article ID: 130004503956
• NII Article ID: 30030410732
• DOI: 10.3408/jasti.9.103
• ISSN: 18822827
• ISSN: 13428713
• ISSN: http://id.crossref.org/issn/0013936X
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed