アレルギーにおける自然免疫応答  [in Japanese] Innate immune responses in allergy  [in Japanese]

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Author(s)

    • 善本 知広 Yoshimoto Tomohiro
    • 兵庫医科大学先端医学研究所アレルギー疾患研究部門 Laboratory of Allergic Diseases, Institute for Advanced Medical Sciences, Hyogo College of Medicine

Abstract

我々は,アレルギー反応にはIgE抗体依存の「獲得型アレルギー」とIgE抗体非依存性の「自然型アレルギー」があり,IL-18とIL-33は「自然型アレルギー」の誘導因子であることを提唱した.特に,IL-33は自然型(好塩基球,マスト細胞,あるいは2型自然リンパ球)と獲得型(Th2細胞)アレルギーに関連する様々な細胞を刺激する結果,生体内で好酸球性炎症を誘導する.従って,IL-33は「自然型アレルギー」と「獲得型アレルギー」に不可欠な調節因子であり,自然型と獲得型のアレルギー疾患双方に対する治療標的として期待される.<br>

We proposed two types of allergic response: IgE-dependent and IgE-independent, and designate these as 'acquired-type allergy' and 'innate-type allergy', respectively. IL-18 and IL-33 are essential regulators for 'innate-type allergy'. Especially, IL-33 stimulates both innate (basophils, mast cells, or group 2 innate lymphoid cells) and acquired (Th2 cells) allergy-related cells to induce and/or augment Th2 cytokine production, which leads to eosinophilic inflammation <i>in vivo</i>. Thus, IL-33 is an essential regulator for both 'innate-type allergy' and 'acquired-type allergy', and might be a therapeutic target for allergic diseases.<br>

Journal

  • Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology

    Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology 27(5), 665-673, 2013

    THE JAPANESE SOCIETY OF PEDIATRIC ALLERGY AND CLINICAL IMMUNOLOGY

Codes

  • NII Article ID (NAID)
    130004504350
  • Text Lang
    JPN
  • ISSN
    0914-2649
  • Data Source
    J-STAGE 
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