Thermochemoradiotherapy for Oral Cancer with N2, 3 Cervical Lymph Node Metastases using Retrograde Superselective Intra-arterial Infusion

• MITSUDO KENJI

  Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine

• KOIZUMI TOSHIYUKI

  Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine

• IIDA MASAKI

  Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine

• MITSUNAGA SACHIYO

  Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine

• TOHNAI IWAI

  Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine

Bibliographic Information

Other Title

• 進行口腔癌の頸部リンパ節転移（N2, 3）に対する逆行性超選択的動注法を用いた温熱化学放射線療法

Abstract

Patients with head and neck squamous cell carcinoma with advanced cervical metastases (N2, 3) have a poor prognosis. This is because patients with N3 disease are generally considered unresectable due to adhesions between metastatic nodes and surrounding tissue, and the patients with N2, 3 treated with chemoradiotherapy experience a very high rate of distant failure. Our strategy for patients with N2, 3 is to use the thermochemoradiotherapy with retrograde superselective intra-arterial infusion. Retrograde superselective intra-arterial chemotherapy for head and neck cancer has the advantage of delivering a high concentration of the chemotherapeutic agents to the tumor bed, and provides daily concurrent radiotherapy and chemotherapy. The use of hyperthermia has generally been confined to cervical lymph node metastases accessible with a radiofrequency system employing external application, and in combination with synergistic chemoradiotherapy. This review demonstrates that thermochemoradiotherapy using intra-arterial infusion provided good histopathologic effects and locoregional control rates for advanced oral cancer patients with N2, 3 cervical lymph node metastases.

Journal

• Thermal Medicine

  Thermal Medicine 28 (2), 23-28, 2012

  Japanese Society for Thermal Medicine

Keywords

• thermochemoradiotherapy
• oral cancer
• superselective intra-arterial infusion
• N2, 3 cervical lymph node metastases

Details

• CRID: 1390001205286646912
• NII Article ID: 130004504391
• NII Article ID: 10030780941
• NII Book ID: AN10084762
• DOI: 10.3191/thermalmed.28.23
• ISSN: 18823750
• ISSN: 18822576
• NDL BIB ID: 023864456
• Web Site: http://id.ndl.go.jp/bib/023864456
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I023864456
• Web Site: https://search.jamas.or.jp/link/ui/2012328908
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed