シンポジウム２０‐３　難治性神経感染症ｕｐｄａｔｅ　亜急性硬化性全脳炎

• 細矢 光亮

  福島県立医科大学医学部小児科

書誌事項

タイトル別名

• Subacute sclerosing panencephalitis (SSPE)

抄録

Subacute sclerosing panencephalitis (SSPE) is a progressive and fatal central nervous system disorder that results from a persistent SSPE virus infection. The efficacy of inosine pranobex, an antiviral/immunomodulator agent, remains controversial. Intraventricular interferon-alpha combined with oral inosine pranobex slows the progressive course of SSPE, but does not cure the disease. We examined a wide variety of antiviral compounds for their inhibitory effects on SSPE virus strains in vitro and in vivo, and found that ribavirin had potent inhibitory activity against SSPE. We tried to treat SSPE patients first with high-dose intravenous ribavirin therapy, and then with intraventricular ribavirin therapy. Ribavirin therapy seemed to have a certain effect on clinical courses of patients with SSPE. To reach the conclusion that ribavirin therapy is clinically effective, clinical trials on many cases will be required.<br>

収録刊行物

• 臨床神経学

  臨床神経学 51 (11), 1047-1050, 2011

  日本神経学会

キーワード

• 亜急性硬化性全脳炎
• リバビリン
• 脳室内投与療法

詳細情報

• CRID: 1390001205035623424
• NII論文ID: 130004504817
• DOI: 10.5692/clinicalneurol.51.1047
• ISSN: 18820654
• ISSN: 0009918X
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
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