大脳基底核疾患の病態生理  [in Japanese] Pathophysiology of movement disorders  [in Japanese]

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Author(s)

    • 南部 篤 Nambu Atsushi
    • 自然科学研究機構生理学研究所,生体システム研究部門 Division of System Neurophysiology, National Institute for Physiological Sciences

Abstract

Malfunctions of the basal ganglia cause movement disorders, such as Parkinson's disease and dystonia. Several models have been proposed to explain the pathophysiology of these disorders: (1) Firing rate model: activity imbalance between the <i>direct</i> and <i>indirect</i> pathways changes the mean firing rate of output nuclei of the basal ganglia and induces hypokinetic or hyperkinetic movement disorders; (2) Firing pattern model: oscillatory and/or synchronized activity observed in the basal ganglia disturbs information processing in the basal ganglia, resulting in motor symptoms; (3) Dynamic activity model: movement-related activity changes through the <i>direct and indirect</i> pathways disrupt balance between movement-related inhibition and surrounding excitation in the output nuclei, and induce motor symptoms. Each model will be critically discussed in this review.<br>

Journal

  • Rinsho Shinkeigaku

    Rinsho Shinkeigaku 52(11), 1198-1200, 2012

    Societas Neurologica Japonica

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