A case of systemic lupus erythematosus predominantly presenting with myositis at onset
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- Endo Yoshinori
- Department of Neurology, Faculty of Medical Sciences, University of Fukui
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- Ikawa Masamichi
- Department of Neurology, Faculty of Medical Sciences, University of Fukui
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- Takahashi Naoki
- Department of Nephrology, Faculty of Medical Sciences, University of Fukui
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- Nishino Ichizo
- Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry
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- Suzuki Shigeaki
- Department of Neurology, Keio University, School of Medicine
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- Yoneda Makoto
- Department of Neurology, Faculty of Medical Sciences, University of Fukui
Bibliographic Information
- Other Title
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- 筋炎が発症時より前景に立った全身性エリテマトーデスの1例
- キンエン ガ ハッショウジ ヨリ ゼンケイ ニ タッタ ゼンシンセイ エリテマトーデス ノ 1レイ
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Abstract
A 42-year-old woman presented with rapid myalgia of the thigh and muscle weakness in the proximal limbs with markedly elevated serum CK. Despite positive for antibodies to anti-nuclear, anti-ds-DNA, anti-ss-DNA, anti-Sm, anti-SS-A/Ro, C-ANCA, anti-U1-RNP and anti-ribosome and slight lymphocytopenia and hypocomplementemia, there was no symptom associated with systemic lupus erythematosus (SLE). Proteinuria and hematuria were initially considered to be associated with renal damage due to myoglobinuria. Muscle MRI demonstrated high signal intensities in the rectus femoris. Muscle biopsy of the rectus femoris demonstrated a mild variation in fiber size, a few necrotic and several regenerating fibers and minimal lymphocytic infiltration in the endomysium, which suggested myopathic changes with mild necrotic and regenerating processes. Thus she was diagnosed as idiopathic myositis at first, and was treated by corticosteroid therapy. Her myalgia and CK level improved, but the proteinuria and hematuria were persistent. A renal biopsy demonstrated lupus nephritis, and SLE with myositis was confirmed. She was treated with additional tacrolimus administration, and her proteinuria and hematuria also improved. The present case suggests that patients who predominantly present with myositis accompanied by nephritis and autoantibodies should be considered as SLE with myositis.
Journal
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- Rinsho Shinkeigaku
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Rinsho Shinkeigaku 53 (8), 634-637, 2013
Societas Neurologica Japonica
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Keywords
Details 詳細情報について
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- CRID
- 1390001205035712768
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- NII Article ID
- 40019778416
- 130004505540
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- NII Book ID
- AN00253207
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- COI
- 1:STN:280:DC%2BC3sbhs12jsA%3D%3D
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- ISSN
- 18820654
- 0009918X
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- NDL BIB ID
- 024827753
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- PubMed
- 23965856
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed