Prognostic significance of CD44v3 and CD44v6 in oral squamous cell carcinoma of the tongue
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Background: CD44, a family of alternatively spliced transmembrane cell adhesion molecules, is expressed in many types of tumors, including oral squamous cell carcinoma. CD44 variant 3 and 6 (CD44v3 and CD44v6) expression in head and neck squamous cell carcinoma has been suggested to correlate with a poor prognosis. We investigated the relationship between CD44 variant forms and clinicopathological parameters in oral squamous cell carcinoma of the tongue (OSCCT). Methods: Immunohistochemical analysis of 60 cases of OSCCT was performed to investigate the relationship of CD44v3 and CD44v6 expression with clinicopathological parameters and clinical outcome. Results: Significant correlations were present between CD44v3 expression and clinicopathological parameters, such as mode of invasion (<i>P</i><0.0001), differentiation type (<i>P</i><0.0001), local recurrence (<i>P</i><0.05), and secondary metastasis to lymph nodes (<i>P</i><0.05). Loss of staining of CD44v3 also significantly correlated with a poor prognosis (<i>P</i><0.001). On the other hand, CD44v6 expression showed no correlation with clinicopathological parameters. Conclusion: CD44v3 may be useful as a diagnostic/prognostic biomarker of OSCCT because low CD44v3 immunoreactivity is associated with high invasive potential and poor prognosis.
- Oral Medicine & Pathology
Oral Medicine & Pathology 15(4), 107-112, 2011
The Japanese Society of Oral Pathology