Prognostic significance of CD44v3 and CD44v6 in oral squamous cell carcinoma of the tongue

• Tsuruoka Shoko

  Division of Oral and Maxillofacial Reconstructive Surgery, Department of Oral and Maxillofacial Surgery, Kyushu Dental College

• Matsuo Kou

  Division of Oral Pathology, Department of Biosciences, Kyushu Dental College

• Ishikawa Ayataka

  Division of Oral Pathology, Department of Biosciences, Kyushu Dental College

• Yamamoto Noriaki

  Division of Oral and Maxillofacial Reconstructive Surgery, Department of Oral and Maxillofacial Surgery, Kyushu Dental College

• Yamashita Yoshihiro

  Division of Oral and Maxillofacial Reconstructive Surgery, Department of Oral and Maxillofacial Surgery, Kyushu Dental College

• Takahashi Tetsu

  Division of Oral and Maxillofacial Reconstructive Surgery, Department of Oral and Maxillofacial Surgery, Kyushu Dental College

抄録

Background: CD44, a family of alternatively spliced transmembrane cell adhesion molecules, is expressed in many types of tumors, including oral squamous cell carcinoma. CD44 variant 3 and 6 (CD44v3 and CD44v6) expression in head and neck squamous cell carcinoma has been suggested to correlate with a poor prognosis. We investigated the relationship between CD44 variant forms and clinicopathological parameters in oral squamous cell carcinoma of the tongue (OSCCT). Methods: Immunohistochemical analysis of 60 cases of OSCCT was performed to investigate the relationship of CD44v3 and CD44v6 expression with clinicopathological parameters and clinical outcome. Results: Significant correlations were present between CD44v3 expression and clinicopathological parameters, such as mode of invasion (P<0.0001), differentiation type (P<0.0001), local recurrence (P<0.05), and secondary metastasis to lymph nodes (P<0.05). Loss of staining of CD44v3 also significantly correlated with a poor prognosis (P<0.001). On the other hand, CD44v6 expression showed no correlation with clinicopathological parameters. Conclusion: CD44v3 may be useful as a diagnostic/prognostic biomarker of OSCCT because low CD44v3 immunoreactivity is associated with high invasive potential and poor prognosis.

収録刊行物

• Ｏｒａｌ　Ｍｅｄｉｃｉｎｅ　＆　Ｐａｔｈｏｌｏｇｙ

  Ｏｒａｌ　Ｍｅｄｉｃｉｎｅ　＆　Ｐａｔｈｏｌｏｇｙ 15 (4), 107-112, 2011

  特定非営利活動法人 日本臨床口腔病理学会

キーワード

• oral squamous cell carcinoma
• tongue
• CD44v3
• CD44v6
• mode of invasion

詳細情報

• CRID: 1390001204470103296
• NII論文ID: 130004509551
• DOI: 10.3353/omp.15.107
• ISSN: 18821537
• ISSN: 13420984
• Web Site: https://search.jamas.or.jp/link/ui/2013080452
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可