A juvenile female patient with non paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis
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- Hamano Nobuyuki
- General Intensive Care Unit, Hirakata Hospital, Kansai Medical University
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- Takahashi Yukitoshi
- Shizuoka Institute of Epilepsy and Neurological Disorders, National Epilepsy Center
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- Okamoto Akihisa
- General Intensive Care Unit, Hirakata Hospital, Kansai Medical University
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- Miki Hirokazu
- General Intensive Care Unit, Hirakata Hospital, Kansai Medical University
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- Sakamoto Sachiyo
- General Intensive Care Unit, Hirakata Hospital, Kansai Medical University
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- Nishi Kenichiro
- General Intensive Care Unit, Hirakata Hospital, Kansai Medical University
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- Nakao Shinichi
- General Intensive Care Unit, Hirakata Hospital, Kansai Medical University
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- Shingu Koh
- General Intensive Care Unit, Hirakata Hospital, Kansai Medical University
Bibliographic Information
- Other Title
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- 若年女性にみられた非腫瘍随伴性抗N-methyl-D-aspartate(NMDA)受容体脳炎の1症例
- 若年女性にみられた非腫瘍随伴性抗N‐methyl‐D‐aspartate(NMDA)受容体脳炎の1症例
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Abstract
Since the report of Dalmau et al. in 2007, anti-N-methyl-D-aspartate (NMDA) receptor encephalitis has received an increasing amount of attention. This condition accounts for some cases of limbic encephalitis and is often paraneoplastic. Here, we report a patient with non paraneoplastic anti-NMDA receptor encephalitis. A 29-year-old woman was admitted to our intensive care unit because of aspiration pneumonia and intractable convulsions. After experiencing common cold symptoms, the patient developed psychiatric symptoms, such as hallucinations and delusions, and persistent limbic convulsions in spite of the administration of several anticonvulsants prior to admission. Her laboratory studies and electroencephalographic examinations were not significant, and no tumor was found. However, a spinal fluid examination revealed a mild elevation in mononuclear cells and protein and the existence of anti-glutamate receptor antibodies, indicating that the limbic encephalitis might have been caused by autologous antibodies. The patient quickly recovered from the pneumonia in response to appropriate antibiotics and respiratory management, and her convulsions (and psychiatric symptoms) were ameliorated with steroid therapy. Limbic encephalitis, including anti-NMDA receptor encephalitis, remains unfamiliar to many physicians, but awareness of this condition is important as anti-NMDA receptor encephalitis accounts for a relevant proportion of unexplained, new-onset convulsions and psychiatric symptoms and is responsive to several therapies, with a favorable prognosis.
Journal
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- Journal of the Japanese Society of Intensive Care Medicine
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Journal of the Japanese Society of Intensive Care Medicine 18 (2), 233-237, 2011
The Japanese Society of Intensive Care Medicine
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Details 詳細情報について
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- CRID
- 1390001204443474176
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- NII Article ID
- 130004514322
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- ISSN
- 1882966X
- 13407988
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed