Role of Coagulation System in Inflammatory Responses of the Airways

DOI 1 Citations 106 References
  • Shimizu Shino
    Department of Otorhinolaryngology, Shiga University of Medical Science

Bibliographic Information

Other Title
  • 気道炎症における凝固系因子とprotease-activated receptorsを介した炎症応答

Search this article

Abstract

Thrombin, an effector enzyme of coagulation system, has important biological functions not only in thrombosis and hemostasis but also in inflammation. Thrombin's precise role in sinonasal inflammation remains unknown but indirect evidence suggests it may play a fundamental role. We found that thrombin aided tissue remodeling by stimulating platelet-derived growth factor (PDGF) secretion and fibroblast or smooth muscle cell prolifration. The natural anticoagulant-activated protein C decreased PDGF expression and suppressed fibrosis in a lung fibrosis mouse model.<br>Elevated procoagulant and suppressed fibrinolytic activity is regularly encountered in different forms of clinical and experimental tissue remodeling of airways. We discuss evidence for impaired regulation of coagulation and fibrinolysis factors in clinical and experimental airway diseases and the role of protease-activated receptors (PARs) induced cellular events, especially in airway epithelial cells. Given experiments in clinical data and animal models of lung fibrosis, asthma, nasal allergy, and chronic rhinosinusitis, we also discuss therapeutic potential for treating of upper airway disease resistant to current therapeutics.

Journal

Citations (1)*help

See more

References(106)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top