OLFACTORY NERVE TRANSPORT OF MACROMOLECULAR DRUGS TO THE BRAIN<br>—A PROBLEM IN OLFACTORY IMPAIRED PATIENTS—

• Shiga Hideaki

  Department of Otorhinolaryngology -Head and Neck Surgery, Kanazawa Medical University

• Yamamoto Junpei

  Department of Otorhinolaryngology -Head and Neck Surgery, Kanazawa Medical University

• Miwa Takaki

  Department of Otorhinolaryngology -Head and Neck Surgery, Kanazawa Medical University

Bibliographic Information

Other Title

• 末梢嗅神経を介した脳内への微小粒子の輸送<br>—嗅覚障害における課題—

Abstract

Nasal administration of macromolecular drugs (including peptides and nanoparticles) has the potential to enable drug delivery system beyond the blood brain barrier (BBB) via olfactory nerve transport. Basic research on drug deliver systems to the brain via nasal administration has been well reported.<br>Insulin-like growth factor-I (IGF-I) is associated with the development and growth of the central nervous system. Clinical application of IGF-I with nasal administration is intended to enable drug delivery to brain through the BBB. Uptake of IGF-I in the olfactory bulb and central nervous system increased according to the dosage of nasally administered IGF-I in normal ICR mice, however IGF-I uptake in the trigeminal nerve remained unchanged. Olfactory nerve transport is important for the delivery of nasally administered IGF-I to the brain in vivo.<br>Because a safe olfactory nerve tracer has not been clinically available, olfactory nerve transport has not been well studied in humans. Nasal thallium-201 (²⁰¹Tl) administration has been safely used to assess the direct pathway to the brain via the nose in healthy volunteers with a normal olfactory threshold. ²⁰¹Tl olfactory nerve transport has recently been shown to decrease in patients with hyposmia. The olfactory nerve transport function in patients with olfactory disorders will be determined using ²⁰¹Tl olfacto-scintigraphy for the exclusion of candidates in a clinical trial to assess the usefulness of nasal administration of IGF-I.

Journal

• JIBI INKOKA TEMBO

  JIBI INKOKA TEMBO 55 (Supplement1), s15-s19, 2012

  Society of Oto-rhino-laryngology Tokyo

Keywords

• insulin-like growth factor-I (IGF-I)
• olfactory nerve transport
• drug delivery to brain
• olfacto-scintigraphy

Details

• CRID: 1390282679929471360
• NII Article ID: 130004546472
• DOI: 10.11453/orltokyo.55.s15
• ISSN: 18836429
• ISSN: 03869687
• Web Site: https://search.jamas.or.jp/link/ui/2013056476
• Text Lang: ja
• Data Source:
  • JaLC
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed