An Autopsy Case of Extramammary Paget's Carcinoma with Brain Metastases and Analysis of the Progress Patterns

DOI
  • YAMANAKA Takashi
    Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University
  • TANEMURA Atsushi
    Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University
  • IIMURO Eriko
    Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University
  • NISHIOKA Megumi
    Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University
  • YAJIMA Tomoko
    Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University
  • TANI Mamori
    Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University
  • WATAYA-KANEDA Mari
    Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University
  • KATAYAMA Ichiro
    Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University
  • NOJIMA Satoshi
    Department of Pathology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University
  • AOZASA Katsuyuki
    Department of Pathology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University
  • HIRAKAWA Satoshi
    Department of Dermatology, Ehime University Graduate School of Medicine
  • HASHIMOTO Koji
    Department of Dermatology, Ehime University Graduate School of Medicine

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Other Title
  • 脳転移を来たした乳房外 Paget 癌の1例：剖検結果と進展様式の考察

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Abstract

We report an autopsy case of Paget's Carcinoma with brain metastases. A 72-year-old man presented with irregular erythema consisting of hyper- and hypo-pigmented macule and ulcerated red nodule on the left inguinal region. He was diagnosed with Paget's carcinoma by skin biopsy. The biopsy specimen showed numerous lymphatic ducts fulfilled with Paget cells in the dermis. 18F-FDG-PET-CT examination demonstrated multiple metastases to lymph nodes and bones superior to the inguinal region. Initially, multiple metastatic lesions seemed to disappear after several courses of chemotherapy. However, the tumors recurred and metastasis spread to the brain within 1 year after initiating comprehensive treatment. An autopsy was performed with written informed consent from the family and these findings suggest how Paget cells metastasized especially to the lung and brain in this patient.Skin Research, 9: 229-236, 2010

Journal

  • Hifu no kagaku

    Hifu no kagaku 9 (3), 229-236, 2010

    Meeting of Osaka Dermatological Association/Meeting of Keiji Dermatological Association

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