Reaction Mechanisms of Nucleic Acid Enzymes, Oxidative Nucleotide Hydrolase MutT and Translesion DNA Polymerase η

• NAKAMURA Teruya

  Graduate School of Pharmaceutical Sciences, Kumamoto University

Bibliographic Information

Other Title

• DNA損傷修復に働く酸化ヌクレオチド分解酵素MutTとDNAポリメラーゼηの反応機構の解明
• 学会賞受賞論文 DNA損傷修復に働く酸化ヌクレオチド分解酵素MutTとDNAポリメラーゼηの反応機構の解明
• ガッカイショウ ジュショウ ロンブン DNA ソンショウ シュウフク ニ ハタラク サンカ ヌクレオチド ブンカイ コウソ MutT ト DNA ポリメラーゼe ノ ハンノウ キコウ ノ カイメイ

Abstract

DNA, which carries genetic information, is easily damaged by reactive oxygen species,UV radiation and chemical agents, and DNA integrity is maintained by various nucleic acid enzymes. We carried out X-ray crystallographic studies of two types of nucleic acid enzymes, oxidative nucleotide hydrolase MutT and translesion DNA polymerase η. In this review, I will describe the mechanism of high substrate specificity for oxidative nucleotides by E. coli MutT and the visualization of nucleotidyl transfer reaction by human DNA polymerase η.

Journal

• Nihon Kessho Gakkaishi

  Nihon Kessho Gakkaishi 56 (2), 123-128, 2014

  The Crystallographic Society of Japan

Details

• CRID: 1390282679066721152
• NII Article ID: 130004552884
• NII Book ID: AN00188364
• DOI: 10.5940/jcrsj.56.123
• ISSN: 18845576
• ISSN: 03694585
• NDL BIB ID: 025528236
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I025528236
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed