Nasopharyngeal carcinoma and Epstein-Barr virus : Diagnosis and treatment

• MURONO Shigeyuki

  Department of Otolaryngology, Head and Neck Surgery, Kanazawa University

• YOSHIZAKI Tomokazu

  Department of Otolaryngology, Head and Neck Surgery, Kanazawa University

Bibliographic Information

Other Title

• EB ウイルスに着目した上咽頭癌の診断と治療

Abstract

Nasopharyngeal carcinoma (NPC) is closely associated with Epstein-Barr virus (EBV). EBV infection in NPC is monoclonal, suggesting that EBV is a causative agent of NPC. This association of NPC with EBV is not only an interest of virologist but also an attractive target of clinical use including diagnosis and treatment for head and neck surgeon. Both serum EBV titer and in situ hybridization for EBERs are already in clinical use. Quantification of serum EBV-DNA reflects disease course, which is expected to get clinically available. On the other hand, there have been several literatures describing EBV-targeting treatments. However, induction of viral lytic cycle as well as anti-viral compound is a candidate for EBV-based treatment of NPC.

Journal

• jibi to rinsho

  jibi to rinsho 56 (Suppl.1), S39-S43, 2010

  JIBI TO RINSHO KAI

Keywords

• DNA
• cidofovir

Details

• CRID: 1390282679547700352
• NII Article ID: 130004555460
• DOI: 10.11334/jibi.56.s39
• ISSN: 21851034
• ISSN: 04477227
• Web Site: https://search.jamas.or.jp/link/ui/2011088334
• Text Lang: ja
• Data Source:
  • JaLC
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed