Biodistribution and Biocompatibility of Poly(lactic acid)-coated SiO<sub>2</sub> Particle

DOI
  • ABE Shigeaki
    Graduate School of Dental Medicine, Hokkaido University
  • SASAKI Akiko
    Graduate School of Dental Medicine, Hokkaido University
  • IWADERA Nobuki
    Graduate School of Dental Medicine, Hokkaido University
  • AKASAKA Tsukasa
    Graduate School of Dental Medicine, Hokkaido University
  • UO Motohiro
    Graduate School of Medical and Dental Science, Tokyo Medical and Dental University
  • WATARI FumioI
    Graduate School of Dental Medicine, Hokkaido University

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Abstract

In this study, we succeeded in preparation and characterization of poly(lactic acid)-coated silicon dioxide particles. Poly(lactic acid) was well-known as a biocompatible polymer. The obtained particles indicated excellent cytocompatibility. For determination of the biodistribution, the obtained particles were administered to mice through the tail vein. After administration, the particles were determined in some organs with energy-dispersed X-ray spectrometer. The polymer-coated silicon dioxide particles were observed in the lung, liver, and spleen. In addition, the particles also detected in the thyroid based on inductively coupled plasma - atomic emission spectroscopy. The distribution behaviors were quite different from non-polymer coated inorganic particles.

Journal

  • Nano Biomedicine

    Nano Biomedicine 3 (2), 300-305, 2011

    Nano Biomedical Society

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