A proposal research for new health check-up items focusing on the future super-aging society in Japan

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Abstract

 Purpose Currently, general health check-ups are carried out as a part of secondary prevention in Japan. Our Tokai University Tokyo Hospital launched anti-aging health check-ups in June 2006. The aim of this check-up system was to point out signs of aging-related disorders at an early stage and to give guidance according to individual results in combating them. These include examination items backed by published evidence in connection with aging related to various disadvantageous conditions. In this study, we tried to classify these items according to aging, then evaluate their relative importance when introducing new biomarkers to general health checks and holistic health screening.<br> Method Five hundred and thirty-six recipients who underwent anti-aging health check-ups at Tokai University Tokyo Hospital between June 2006 and April 2010 were included in the study. These consisted of 299 males and 254 females, and their age range was 30 y/o to 89 y/o with a mean age of 62.6±7.6 years. PWV, IMT, LDL-C, HDL-C, FFA, hs-CRP, TG, 8-OHdG, IPs, vitamin A, B12, folic acid, IGF- 1, DHEA-s, free testosterone in males, estrogen in females, free-T4, adiponectin, blood pressure, HbA1c and cystatin C were measured, and the gender and ten-years age specific averages and standard deviations were expressed. The correlation between age and the results of individual items were statistically analyzed using Pearson product-moment correlation coefficient analysis. Items that showed a significant change with aging (p<0.01) were identified as “aging markers” and those that showed a tendency to change (p<0.05) as “aging associated markers”.<br> Results The results showed that baPWV, IMT, FFA, Estradiol, DHEA-s, systolic blood pressure and cystatin-C were included as “aging markers”, which strongly reflect aging related change. On the other hand, IGF-1, free testosterone and adiponectin (males) were thought to be “aging associated markers”, which showed a tendency towards aging-related change. Others have evidence of links to these markers, and can be called aging modulating factors.<br> Conclusions A trial study was conducted to propose new examination items for general health check-ups using our anti-aging health check-up data. In combination with our previous publication, many aging and aging-related items can be changed directly or indirectly through modulating factors. Our study indicated that incorporating aging-related items in general health check-ups should be beneficial when considering the benefits focusing on the future super-aging society in Japan.

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