Food Allergen-induced IgE Response Mouse Model Created by Injection of <i>in vitro</i> Differentiated Th2 Cell Culture and Oral Antigen Intake

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著者

    • SHIBAHARA Kyoko
    • Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan|Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
    • NAKAJIMA-ADACHI Haruyo
    • Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
    • KAMINUMA Osamu
    • Department of Genome Medicine, Pollen Allergy Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6, Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan
    • HIROI Takachika
    • Department of Genome Medicine, Pollen Allergy Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6, Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan
    • MORI Akio
    • Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital, 18-1 Sakuradai, Sagamihara-shi, Kanagawa 252-0392, Japan
    • HACHIMURA Satoshi
    • Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan|Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan

抄録

Immunoglobulin (Ig) E is a mediator of food allergic reaction; however, the mechanisms of its production in response to an ingested antigen are not fully understood. For analysis of IgE production, here we propose an IgE response mouse model created by injection of a Th2 cell culture and feeding of an egg white diet. According to this manipulation, total and ovalbumin specific IgE production were elevated in this model. We think our model enables us to analyze IgE induction by Th2 cells in food allergy and can contribute to the development of a treatment for food allergy.

収録刊行物

  • Bioscience of Microbiota, Food and Health

    Bioscience of Microbiota, Food and Health 33(1), 41-46, 2014

    BMFH出版会

キーワード

各種コード

  • NII論文ID(NAID)
    130004562682
  • 本文言語コード
    ENG
  • データ提供元
    J-STAGE 
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