Background of the Irritable Bowel Syndrome: Psychological Factor and Hereditary Determinant

DOI
  • HAMAGUCHI Toyohiro
    Department of Behavioral Medicine, Tohoku University Graduate School of Medicine Department of Occupational Therapy, Niigata University of Health and Welfare, School of Health Sciences
  • KANAZAWA Motoyori
    Department of Behavioral Medicine, Tohoku University Graduate School of Medicine
  • FUKUDO Shin
    Department of Behavioral Medicine, Tohoku University Graduate School of Medicine

Bibliographic Information

Other Title
  • 過敏性腸症候群の背景：心理と遺伝要因

Abstract

Visceral pain sensitivity has been called a biological marker for irritable bowel syndrome (IBS). Recently developed symptom-based criteria provide the tools necessary to make a diagnosis and treatments. The precise underlying pathophysiology of IBS remains unknown. This article is a review of the psychological influences on visceral perception and hereditary determinant for background of IBS. Psychological factors influence pain thresholds in patients with IBS. Sensitization by repeated distention has been cited as evidence of a biological basis for hyperalgesia, and study of the brain imaging shows that different regions are activated by painful distention in patients with IBS. Variation of the gene promoter region is associated with sensitivity to stress and symptoms of IBS, this is consistent with psychological influences on perception. The brain-gut axis involving the central nervous system with genotype and psychological factors have emerged as an underlying concept for IBS.

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Keywords

Details 詳細情報について

  • CRID
    1390282680485665792
  • NII Article ID
    130004623056
  • DOI
    10.11331/jjbm.13.1
  • ISSN
    21880085
    13416790
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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