睡眠時間は主観的健康観及び精神神経免疫学的反応と関連する  [in Japanese] Sleeping Time Relates to Perceived Health and Psychoneuroimmunological Responses  [in Japanese]

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Abstract

大学生の睡眠時間と心身の健康との関連性を明らかにするために、GHQ-28による主観的評定と精神神経免疫学的(PNI)反応[3-methoxy-4-hydroxyphenylglychol(MHPG)含有量、免疫グロブリン(Ig)A抗体産生量]を用いた客観的評価から、睡眠時間の長さによって、心身のストレスの自覚とノルアドレナリン神経系と免疫系の活性がどのように異なるのか検討した。研究参加の同意が得られた健康な大学生205名(男性110名、女性95名、年齢18.6±1.0)を対象に睡眠時間を調査し、最適睡眠時間群(AS:Adequate Sleep)(6〜8時間睡眠)を35名、短時間睡眠群(SS: short sleep)(5時間以下の睡眠)33名と長時間睡眠群(LS: long sleep)(9時間以上の睡眠)28名をそれぞれ抽出した。講義時に、集団一斉法にてGHQ-28への記入を求め、PNI反応を測定するために唾液の採取を行った.LS群のGHQ-28得点は、「社会的活動障害」および「うつ傾向」下位尺度でAS群とSS群に比較して有意に高値であった。一方、SS群はASに比較して「身体症状」下位尺度得点が有意に高かった。SS群の唾液中free-MHPGは、AS群と異ならなかったが、LS群に比較して有意に高く、s-IgAは有意に低かった。ロジスティック回帰分析の結果は、中等度以上の「身体的症状」、「社会的活動障害」と「うつ傾向」症状が短時間もしくは長時間睡眠と有意に関連していることを明らかにした。以上の知見から、6〜8時間睡眠が最も心身の健康と関連していることが示された。また、睡眠時間いかんによって唾液を指標にして得られたPNI反応が異なったことは、今後、大学生のストレス関連疾患の予防や健康増進活動のために、睡眠の重要性を示す客観的証拠となると考える。

The present study was to assess the relationship between sleeping time and the health of mind-body. Both subjective and objective outcome measurements such as General Health Questionnaire (GHQ)-28 and Psychoneuroimmunological (PNI) responses [3-methoxy-4-hydroxyphenylglychol(MHPG), immunoglobulin(Ig)-A] were used to assess the state of health and stress. Subjects were 205 healthy university students (110 males and 95 females). These subjects were divided by habitual sleeping time: adequate sleepers (AS) (6–8 hour sleep per night regularly) (n=35), short sleepers (SS) (less than 5 hour sleep per night regularly) (n=33) and long sleepers (LS) (more than 8 hour sleep per night regularly) (n=28). Subjects completed the questionnaire of GHQ-28 while the saliva samples were collected by chewing cotton swab, SALIVETTE, in the mouth during a lecture. Subscale scores of Social Dysfunction and Depression on GHQ-28 in LS were significantly higher than those in AS and SS. In addition to those, the scores of Somatic Symptoms on GHQ-28 in SS and LS were higher than AS. Levels of free-MHPG in SS were higher than those in LS, although free-MHPG levels in AS did not differ from SS and LS. The levels of s-IgA in SS were significantly lower than those in AS. The results of the logistic regression analysis indicated that both shorter sleep and longer sleep was associated with high scores of Somatic Symptoms, Social Dysfunction and Depression. These results demonstrated that sleeping time relates to perceived health and change in PNI function. Moreover, the results of PNI responses and GHQ-28 suggest that sleeping time is very important factor for prevention of stress disease and health promotion for university students.

Journal

  • Japanese Journal of Behavioral Medicine

    Japanese Journal of Behavioral Medicine 15(1), 33-40, 2010

    The Japanese Society of Behavioral Medicine

Codes

  • NII Article ID (NAID)
    130004623067
  • Text Lang
    JPN
  • ISSN
    1341-6790
  • Data Source
    J-STAGE 
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