Uptake and Clearance of 7, 12-Dimethylbenz [a] anthracene Injected Intravenously to Rats on High Fat Diets
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There is considerable evidence to support that the unique sensitivity of certain tissues to systemic administration of carcinogenic agents is due, in part, to localization of the agents within them. In general, hydrocarbons are cleared from the body rapidly. In contrast, the adipose tissues are slow in clearing carcinogens. In the mammary adipose tissue, the fat pad might appear to act as a carcinogen trap, retaining the unchanged hydrocarbon within the fat cells, from which it is released slowly. Mammary carcinogenesis with 7,12-dimethylbenz Cap anthracene (DMBA) was enhanced by the high fat diets given to the host, especially a high corn oil diet. The influence might be due either to an abnormal trap of the altered adipose tissue or to direct and indirect effects of the ingested upon the metabolism of tumor tissues. To examine how a high fat diet acts mammary carcingenesis, an experiment was carried out in which the concentration of labeled DMBA in various organs of the rats on high fat diets was determined at various time intervals after a single intravenous injection of hot DMBA emulsion. The results of the investigation are presented in this communication.
- The Journal of Kansai Medical University
The Journal of Kansai Medical University 23(Supplement), S29-S34, 1971
The Medical Society of Kansai Medical University