Role of carnitine acetylation in skeletal muscle
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- Furuichi Yasuro
- Department of Health Promotion Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University
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- Goto-Inoue Naoko
- Department of Health Promotion Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University Department of Cell Biology and Anatomy, Hamamatsu University School of Medicine
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- L. Fujii Nobuharu
- Department of Health Promotion Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University
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Abstract
Carnitine is known for its role in the transport of long-chain fatty acids into the mitochondrial matrix for subsequent β-oxidation. In addition, carnitine acts as an acceptor of excess acetyl-CoA and forms acetylcarnitine to relieve inhibition of pyruvate dehydrogenase. Recent studies have demonstrated that carnitine acetylation is essential for glucose homeostasis, and its dysfunction induces metabolic failure. Furthermore, it has been suggested that acetylcarnitine might be exported from skeletal muscle into the blood. Considering that acetylcarnitine is a bioactive molecule involved in glucose metabolism and neuroprotection, we expect that acetylcarnitine production is beneficial to the body. In this article, we reviewed recent knowledge on the role of carnitine acetylation in glucose metabolism within skeletal muscle. Furthermore, this article introduces acetylcarnitine as a physiologically active substance and discusses carnitine dynamics during exercise.
Journal
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- The Journal of Physical Fitness and Sports Medicine
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The Journal of Physical Fitness and Sports Medicine 3 (2), 163-168, 2014
The Japanese Society of Physical Fitness and Sports Medicine
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Details 詳細情報について
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- CRID
- 1390282680392955392
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- NII Article ID
- 130004626091
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- NII Book ID
- AA12573156
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- ISSN
- 21868123
- 21868131
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- NDL BIB ID
- 025478791
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed