Angiogenic defects in preeclampsia: What is known, and how are such defects relevant to preeclampsia pathogenesis?

• Kanasaki Keizo

  Department of Diabetology and Endocrinology, Kanazawa Medical University

• Kanasaki Megumi

  Department of Diabetology and Endocrinology, Kanazawa Medical University

抄録

Preeclampsia is a devastating pregnancy-associated hypertensive syndrome. Although it is quite common, the pathophysiology of preeclampsia is not yet clear and remains “a disease of theory”. Angiogenic defect hypotheses have been intensively investigated, and some biomarkers have been independently analyzed as pathogenic clinical target molecules without direct proof of their roles in preeclampsia. In this review, we assessed an up-to-date list of proposed angiogenic defects for their relevance to preeclampsia. In addition, we introduce our working hypothesis of preeclampsia pathophysiology, which involves interactions between metabolic and angiogenic defects.

収録刊行物

• Hypertension Research in Pregnancy

  Hypertension Research in Pregnancy 1 (2), 57-65, 2013

  日本妊娠高血圧学会

キーワード

• 2-ME2
• angiogenesis
• sFlt1
• soluble receptor
• VEGF receptor

詳細情報

• CRID: 1390282680485560064
• NII論文ID: 130004638238
• DOI: 10.14390/jsshp.1.57
• ISSN: 21879931
• ISSN: 21875987
• Web Site: https://www.jstage.jst.go.jp/article/jsshp/1/2/1_57/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2015032756
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可