Pulmonary vein myocardium as a possible pharmacological target of atrial fibrillation
-
- Takahara Akira
- Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Japan
-
- Hagiwara Mihoko
- Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Japan
-
- Namekata Iyuki
- Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Japan
-
- Tanaka Hikaru
- Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Japan
書誌事項
- タイトル別名
-
- Pulmonary Vein Myocardium as a Possible Pharmacological Target for the Treatment of Atrial Fibrillation
この論文をさがす
抄録
The pulmonary vein has a unique electrophysiological property showing an autonomic electrical activity, and this phenomenon has been further focused on as a source of triggers of atrial fibrillation. The pulmonary vein cardiomyocytes have shorter action potential duration, less negative resting membrane potential, and smaller maximum upstroke velocity than those in the left atrium, whose underlying cellular mechanisms may generate arrhythmogenic substrates such as abnormal automaticity and triggered activity. In diseased conditions including sustained atrial tachycardia or chronic volume overload, its arrhythmogenic profile can be further modified through abbreviation of action potential duration of the pulmonary vein myocardium, which may become a cause of reentry. Recently, antiarrhythmic effects of various drugs have been extensively investigated in isolated pulmonary vein preparations. The present review article highlights the recent advances in our understanding of electrophysiological and pharmacological profiles of the pulmonary vein.
収録刊行物
-
- Journal of Pharmacological Sciences
-
Journal of Pharmacological Sciences 126 (1), 1-7, 2014
公益社団法人 日本薬理学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282680155488640
-
- NII論文ID
- 130004677805
-
- NII書誌ID
- AA11806667
-
- COI
- 1:CAS:528:DC%2BC2cXhs1OgsL%2FK
-
- ISSN
- 13478648
- 13478613
-
- NDL書誌ID
- 025790466
-
- PubMed
- 25242082
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
-
- 抄録ライセンスフラグ
- 使用不可