Association between subclinical hypothyroidism and diabetic nephropathy in patients with type 2 diabetes mellitus
-
- Furukawa Shinya
- Department of Public Health, Ehime University Graduate School of Medicine, Toon 791-0295, Japan
-
- Yamamoto Shin
- Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon 791-0295, Japan
-
- Todo Yasuhiko
- Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon 791-0295, Japan
-
- Maruyama Kotatsu
- Department of Basic Research and Education, Ehime University Graduate School of Medicine, Toon 791-0295, Japan
-
- Miyake Teruki
- Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon 791-0295, Japan
-
- Ueda Teruhisa
- Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon 791-0295, Japan
-
- Niiya Tetsuji
- Department of Internal Medicine, Matsuyama City Hospital, Matsuyama 790-0067, Japan
-
- Senba Takatoshi
- Department of Internal Medicine, Matsuyama City Hospital, Matsuyama 790-0067, Japan
-
- Torisu Masamoto
- Department of Internal Medicine, Saiseikai Saijo Hospital, Saijo 793-0027, Japan
-
- Kumagi Teru
- Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon 791-0295, Japan
-
- Miyauchi Syozo
- Department of Internal Medicine, Uwajima City Hospital, Uwajima 798-8510, Japan
-
- Sakai Takenori
- Department of Internal Medicine, Yawatahama General City Hospital, Yawatahama 796-8502, Japan
-
- Minami Hisaka
- Department of Internal Medicine, Ehime Niihama Hospital, Niihama 792-0042, Japan
-
- Miyaoka Hiroaki
- Department of Internal Medicine, Saiseikai Matsuyama Hospital, Matsuyama 791-8026, Japan
-
- Matsuura Bunzo
- Department of Lifestyle-related Medicine and Endocrinology, Ehime University Graduate School of Medicine, Toon 791-0295, Japan
-
- Hiasa Yoichi
- Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon 791-0295, Japan
-
- Onji Morikazu
- Department of Internal Medicine, Saiseikai Imabari Hospital, Imabari 799-1592, Japan
-
- Tanigawa Takeshi
- Department of Public Health, Ehime University Graduate School of Medicine, Toon 791-0295, Japan Department of Public Health, Juntendo University Graduate School Medicine, Tokyo 113-8421, Japan
Search this article
Abstract
Subclinical hypothyroidism (SCH) has been associated with type 2 diabetes mellitus. However, it is unknown whether common complications of type 2 diabetes, such as diabetic nephropathy, are also present with SCH. Here, we investigated the association between SCH and diabetic nephropathy among Japanese patients with type 2 diabetes mellitus. In this multicenter cross-sectional study, we recruited 414 such patients who had no previous history of thyroid disease. Serum thyroid hormone levels and the urinary albumin:creatinine ratio were measured. SCH was defined as an elevated thyroid-stimulating hormone (TSH) level (>4.0 mIU/L), and diabetic nephropathy was defined as urinary albumin/creatinine ratio ≥300 mg/g. The prevalence of SCH was 8.7% (n = 36) among patients with type 2 diabetes mellitus. The SCH group had a higher prevalence of dyslipidemia (p = 0.008) and diabetic nephropathy (p = 0.014) than the euthyroid group. Multivariate analysis identified significant positive associations between diabetic nephropathy and SCH (odds ratio [OR], 3.51; 95% confidence interval [CI], 1.10−10.0; p = 0.034), hypertension (OR, 4.56; 95% CI, 1.69−14.7; p = 0.001), and smoking (OR, 3.02; 95% CI, 1.14−7.91; p = 0.026). SCH may be independently associated with diabetic nephropathy in Japanese patients with type 2 diabetes mellitus.
Journal
-
- Endocrine Journal
-
Endocrine Journal 61 (10), 1011-1018, 2014
The Japan Endocrine Society
