Circulating TNF Receptor 2 is Closely Associated with the Kidney Function in Non-Diabetic Japanese Subjects
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- Kurashina Tomoyuki
- Division of Endocrinology and Metabolism, Jichi Medical University
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- Nagasaka Shoichiro
- Division of Endocrinology and Metabolism, Jichi Medical University
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- Watanabe Naoya
- Health Care and Promotion Center, Yodogawa Christian Hospital
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- Yabe Daisuke
- Division of Diabetes, Clinical Nutrition and Endocrinology, Kansai Electric Power Hospital
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- Sugi Noriko
- Kyoto Oral Health Center, Rakuwakai Otowa Hospital
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- Nin Kazuko
- Human Health Sciences, Graduate School of Medicine, Kyoto University
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- Hosokawa Masaya
- Faculty of Human Sciences, Tezukayama Gakuin University
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- Nomura Yoshio
- Department of Oral Health, Kobe Tokiwa University Junior College
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- Fukushima Mitsuo
- Division of Clinical Nutrition and Internal Medicine, Okayama Prefectural University
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- Nakai Yoshikatsu
- Kyoto Institute of Health Science
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- Nishimura Fusanori
- Section of Periodontology, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University
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- Taniguchi Ataru
- Division of Diabetes and Endocrinology, Kyoto Preventive Medical Center
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Abstract
Aim: Chronic kidney disease (CKD) is associated with cardiovascular events. Tumor necrosis factor (TNF) and/or its receptors have been postulated to be involved in renal pathophysiology. It is unclear whether an increased TNF system activity is present before the development of apparent CKD.<br> Methods: Four hundred and twenty non-diabetic Japanese subjects with an estimated GFR (eGFR) greater than 60 ml/min/1.73 m2 were recruited for measurement of the HbA1c, insulin, TNF system activity (TNF-α, soluble TNF receptor 1 (sTNF-R1) and sTNF-R2) levels and various parameters, including the lipid, high-sensitivity C-reactive protein (hsCRP), high-molecular-weight (HMW) adiponectin and leptin levels. The subjects were stratified according to the eGFR: the G1 level (eGFR ≧90 ml/min/1.73 m2) and the G2 level (90 ＞eGFR ≧60 ml/min/1.73 m2).<br> Results: Whereas no significant differences were observed in gender, body mass index (BMI), blood pressure, insulin, TNF-α, hsCRP, HMW adiponectin or leptin between the two groups, the values for age, HbA1c, triglycerides, sTNF-R1 and sTNF-R2 were significantly higher in the subjects with a G2 level of eGFR than in those with a G1 level. In contrast, the HDL cholesterol levels were significantly lower in the subjects with a G2 level than in those with a G1 level. Linear negative correlations were also observed between eGFR and age, BMI, HbA1c, triglycerides, sTNF-R1 and sTNFR2, respectively. A multiple logistic regression analysis revealed that only sTNF-R2 was associated with the presence of a G2 level of eGFR (Odds ratio 1.092, 95% CI 1.013-1.177, P=0.021).<br> Conclusions: The circulating sTNF-R2 level is closely associated with the kidney function in non-diabetic Japanese subjects.
Journal
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- Journal of Atherosclerosis and Thrombosis
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Journal of Atherosclerosis and Thrombosis 21 (7), 730-738, 2014
Japan Atherosclerosis Society