Lung Adenocarcinoma Complicated by Trousseau's Syndrome Successfully Treated by a Combination of Anticoagulant Therapy and Chemotherapy
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- Yoshii Yutaka
- Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Japan
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- Numata Takanori
- Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Japan
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- Ishitobi Wakako
- Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Japan
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- Takahashi Naoko
- Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Japan
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- Wakui Hiroshi
- Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Japan
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- Kojima Jun
- Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Japan
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- Shimizu Kenichiro
- Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Japan
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- Hara Hiromichi
- Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Japan
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- Ishikawa Takeo
- Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Japan
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- Kawaishi Makoto
- Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Japan
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- Saito Keisuke
- Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Japan
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- Araya Jun
- Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Japan
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- Kaneko Yumi
- Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Japan
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- Nakayama Katsutoshi
- Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Japan
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- Kuwano Kazuyoshi
- Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Japan
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Abstract
A 63-year-old woman was diagnosed with advanced lung adenocarcinoma complicated by Trousseau's syndrome characterized by non-bacterial thrombotic endocarditis, asymptomatic brain infarction, deep venous thrombosis, and low-grade disseminated intravascular coagulation (DIC). The patient's DIC rapidly became widespread, and multiple micropulmonary embolisms led to severe respiratory failure. She received a blood transfusion and anticoagulant treatment with heparin and recombinant human soluble thrombomodulin, which modestly ameliorated her symptoms, and additional chemotherapy led to tumor shrinkage with concomitant resolution of Trousseau's syndrome. Although there are no established medical approaches for managing Trousseau's syndrome, intensive anticoagulant treatment may be effective for improving the patients' general condition in order for them to be able to undergo subsequent combination chemotherapy.<br>
Journal
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- Internal Medicine
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Internal Medicine 53 (16), 1835-1839, 2014
The Japanese Society of Internal Medicine