Identification of novel omega-3 fatty acid-derived bioactive metabolites based on a targeted lipidomics approach

Access this Article

Search this Article

Author(s)

    • Isobe Yosuke
    • Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences (IMS)
    • Arita Makoto
    • Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences (IMS)|Graduate School of Medical Life Science, Yokohama City University|PRESTO, JST

Abstract

Omega-3 polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid have beneficial effects in many inflammatory disorders. Although the mechanism of eicosapentaenoic acid and docosahexaenoic acid action is still not fully defined in molecular terms, recent studies have revealed that, during the course of acute inflammation, omega-3 polyunsaturated fatty acid-derived anti-inflammatory mediators including resolvins and protectins are produced. This review presents recent advances in understanding the formation and action of these mediators, especially focusing on the LC-MS/MS-based lipidomics approach and recently identified bioactive products with potent anti-inflammatory property.

Journal

  • Journal of Clinical Biochemistry and Nutrition

    Journal of Clinical Biochemistry and Nutrition 55(2), 79-84, 2014

    SOCIETY FOR FREE RADICAL RESEARCH JAPAN

Codes

  • NII Article ID (NAID)
    130004678432
  • Text Lang
    ENG
  • ISSN
    0912-0009
  • Data Source
    J-STAGE 
Page Top