<b>Carcinoembryonic antigen-related cell adhesion molecule 4 (CEACAM4) is specifically expressed in medullary thyroid carcinoma </b><b>cells </b>

• WAKABAYASHI-NAKAO Kanako

  Medical Genetics Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan

• HATAKEYAMA Keiichi

  Medical Genetics Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan

• OHSHIMA Keiichi

  Medical Genetics Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan

• Ken YAMAGUCHI Ken

  Shizuoka Cancer Center Hospital and Research Institute, Shizuoka, Japan

• MOCHIZUKI Tohru

  Medical Genetics Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan

Bibliographic Information

Other Title

• Carcinoembryonic antigen-related cell adhesion molecule 4 (CEACAM4) is specifically expressed in medullary thyroid carcinoma cells

Abstract

Carcinoembryonic antigen (CEA), an oncofetal cell surface glycoprotein, has been widely used as a human tumor marker due to its high expression in tumors and secretion to serum. It belongs to the immunoglobulin superfamily named CEA-related cell adhesion molecule (CEACAM) family. Members of this family are detected in various cancers and have been shown to be involved in cancer growth and invasion. In this study, we examined the mRNA expression profiles of CEACAM family members including CEACAM1, CEACAM3, CEACAM4, CEACAM5 (CEA), CEACAM6, CEACAM7, and CEACAM8 in various tumor cell lines. Our screening data indicated that the mRNA expression patterns of CEACAMs in TT cells, which are derived from medullary thyroid carcinoma (MTC), were distinct from other tumor cell lines. Additionally, CEACAM4 was only expressed in TT cells, in which two novel splice variants of CEACAM4 were expressed. These findings suggested that production of CEA and CEA-related molecules in MTC may be distinct from other tumor-based production of those molecules and that the specific expression of CEACAM4 would make possible to differentiate between MTC and other CEA-producing tumors.

Journal

• Biomedical Research

  Biomedical Research 35 (4), 237-242, 2014

  Biomedical Research Press

Keywords

• General Biochemistry, Genetics and Molecular Biology
• General Medicine

Details

• CRID: 1390001204902299136
• NII Article ID: 130004678579
• DOI: 10.2220/biomedres.35.237
• COI: 1:CAS:528:DC%2BC2cXhsV2lsLbE
• ISSN: 1880313X
• ISSN: 03886107
• PubMed: 25152032
• Web Site: https://search.jamas.or.jp/link/ui/2015176172
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed