Two cases of acute onset of focal cortical reflex myoclonus following acute aseptic meningoencephalitis with positive anti-glutamate receptor autoantibody

DOI Web Site PubMed 9 References Open Access
  • Tojima Maya
    Department of Neurology, Kyoto University Hospital
  • Hitomi Takefumi
    Department of Neurology, Kyoto University Hospital Department of Respiratory Care and Sleep Control Medicine & Department of Clinical Laboratory Medicine, Kyoto University Graduate School of Medicine
  • Jingami Naoto
    Department of Neurology, Kyoto University Hospital
  • Tanioka Kosuke
    Department of Neurology, Kyoto University Hospital
  • Yamakado Hodaka
    Department of Neurology, Kyoto University Hospital
  • Matsumoto Riki
    Department of Neurology, Kyoto University Hospital Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine
  • Takahashi Yukitoshi
    National Epilepsy Center, Shizuoka institute of Epilepsy and Neurological Disorders
  • Ikeda Akio
    Department of Neurology, Kyoto University Hospital Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine
  • Takahashi Ryosuke
    Department of Neurology, Kyoto University Hospital

Bibliographic Information

Other Title
  • 急性無菌性髄膜脳炎の経過中に局所性皮質反射性ミオクローヌスを呈し抗グルタミン酸受容体抗体が検出された2例
  • キュウセイ ムキンセイ ズイマク ノウエン ノ ケイカ チュウ ニ キョクショセイ ヒシツ ハンシャセイ ミオクローヌス オ テイシ コウグルタミンサン ジュヨウタイ コウタイ ガ ケンシュツ サレタ 2レイ

Search this article

Abstract

Patient 1 was a 40-year-old man, who suffered from right leg myoclonus 1 week after an episode of fever and headache. Myoclonus disappeared 4 months after administration of clonazepam. Patient 2 was a 42-year-old man, who suffered from right leg myoclonus, attacks of speech arrest and a generalized tonic-clonic seizure. His symptoms disappeared after steroid-pulse therapy, but right leg myoclonus and episodic impairment of consciousness recurred within a month. He underwent another steroid-pulse therapy and his symptoms disappeared. In both patients, cerebrospinal fluid (CSF) study showed pleocytosis and elevated protein level, electrophysiological study showed cortical reflex by stimulation of the right tibial nerve, and brain MRI showed the high intensity area in the left parietal lobe. In addition, on electroencephalogram (EEG) spikes at vertex preceded myoclonic jerk of the right tibialis anterior muscle in both patients. These findings indicate that focal cortical reflex myoclonus was accompanied by acute central nervous system (CNS) infection. Furthermore, in both patients, autoantibody against glutamate receptor subunits ε2 was detected both in serum and CSF, which also suggest that autoimmune mechanism contributed in the pathophysiology of acute development of focal cortical reflex myoclonus.

Journal

  • Rinsho Shinkeigaku

    Rinsho Shinkeigaku 54 (7), 543-549, 2014

    Societas Neurologica Japonica

References(9)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top