Lactobacillus acidophilus L-92 cells activate expression of immunomodulatory genes in THP-1 cells.

DOI 機関リポジトリ Web Site 被引用文献2件 参考文献28件 オープンアクセス
  • YANAGIHARA Sae
    Microbiology and Fermentation Laboratory, Calpis Co. Ltd., Japan
  • GOTO Hiroaki
    Microbiology and Fermentation Laboratory, Calpis Co. Ltd., Japan
  • HIROTA Tatsuhiko
    Microbiology and Fermentation Laboratory, Calpis Co. Ltd., Japan
  • FUKUDA Shinji
    Intestinal Microbe Symbiosis Laboratory, RIKEN, Japan Laboratory for Intestinal Ecosystem, RCAI, RIKEN Center for Integrative Medical Sciences, Japan Immunobiology Laboratory, Graduate School of Medical Life Science, Yokohama City University, Japan Institute for Advanced Biosciences, Keio University, Japan
  • OHNO Hiroshi
    Intestinal Microbe Symbiosis Laboratory, RIKEN, Japan Laboratory for Intestinal Ecosystem, RCAI, RIKEN Center for Integrative Medical Sciences, Japan Immunobiology Laboratory, Graduate School of Medical Life Science, Yokohama City University, Japan
  • YAMAMOTO Naoyuki
    Intestinal Microbe Symbiosis Laboratory, RIKEN, Japan Research and Development Planning Department, Calpis Co. Ltd., Japan

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  • <i>Lactobacillus acidophilus</i> L-92 Cells Activate Expression of Immunomodulatory Genes in THP-1 Cells

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To understand the immunomodulatory effects of Lactobacillus acidophilus L-92 cells suggested from our previous study of in vivo anti-allergy and anti-virus effects, host immune responses in macrophage-like THP-1 cells after 4 h (the early phase) and 24 h (the late phase) of cocultivation with L-92 cells were investigated by transcriptome analysis. In the early phase of L-92 treatment, various transcription regulator genes, such as, NFkB1, NFkB2, JUN, HIVEP2 and RELB, and genes encoding chemokines and cytokines, such as CCL4, CXCL11, CCL3 and TNF, were upregulated. Two transmembrane receptor genes, TLR7 and ICAM1, were also upregulated in the early phase of treatment. In contrast, many transmembrane receptor genes, such as IL7R, CD80, CRLF2, CD86, CD5, HLA-DQA1, IL2RA, IL15RA and CSF2RA, and some cytokine genes, including IL6, IL23A and CCL22, were significantly upregulated in the late phase after L-92 exposure. Some genes encoding cytokines, such as IL1A, IL1B and IL8, and the enzyme IDO1 were upregulated at both the early and the late phases of treatment. These results suggest that probiotic L-92 might promote Th1 and regulatory T-cell responses by activation of the MAPK signaling pathway, followed by the NOD-like receptor signaling pathway in THP-1 cells.

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