Photodynamic Diagnoses of Malignant Pleural Diseases Using the Autofluorescence Imaging System
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- Kitada Masahiro
- Department of Respiratory Center, Asahikawa Medical University, Asahikawa, Hokkaido, Japan
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- Ohsaki Yoshinobu
- Department of Respiratory Center, Asahikawa Medical University, Asahikawa, Hokkaido, Japan
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- Matsuda Yoshinari
- Department of Respiratory Center, Asahikawa Medical University, Asahikawa, Hokkaido, Japan
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- Hayashi Satoshi
- Department of Respiratory Center, Asahikawa Medical University, Asahikawa, Hokkaido, Japan
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- Ishibashi Kei
- Department of Respiratory Center, Asahikawa Medical University, Asahikawa, Hokkaido, Japan
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Abstract
Background: We conducted a study on photodynamic diagnosis (PDD) using autofluorescence in video-assisted thoracic surgery for minute intrathoracic small dissemination or early malignant pleural mesothelioma.Methods: Autofluorescence is the spontaneous emission of light that occurs when mitochondria, lysosomes, and other intracellular organelles absorb light. In normal tissues, green autofluorescence of approximately 520 nm is observed in response to 400–450 nm blue excitation rays. However, in cancer lesions, green autofluorescence is reduced due to thickening of the mucosal epithelium, a decrease in autofluorescent substances, etc., and the color spectrum thus shifts to red-violet. This phenomenon is the basis of PDD.Results: The color spectrum shift was observed in all tumors located on the pleural surface but not in cases with pleural fibrous disease. Among patients with primary lung cancer, those with pleural infiltration (pl) scores of 1 or greater showed color spectrum shifts due to reduced autofluorescence.Conclusion: Localization of pleural lesions by autofluorescence imaging was found to be useful. In primary lung cancer cases, differentiation between pl0 and pl1 lesions appears to be useful for determining therapeutic strategies including surgical procedures.
Journal
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- Annals of Thoracic and Cardiovascular Surgery
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Annals of Thoracic and Cardiovascular Surgery 20 (5), 378-382, 2014
The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery
