α-Heteroarylation of Ketones <i>via</i> the Umpolung Reaction of <i>N</i>-Alkoxyenamine

• Miyoshi Tetsuya

  Kobe Pharmaceutical University

• Takeda Norihiko

  Kobe Pharmaceutical University

• Fukami Masaki

  Kobe Pharmaceutical University

• Sato Shohei

  Kobe Pharmaceutical University

• Ueda Masafumi

  Kobe Pharmaceutical University

• Miyata Okiko

  Kobe Pharmaceutical University

Bibliographic Information

Other Title

• α-Heteroarylation of Ketones via the Umpolung Reaction of N-Alkoxyenamine

Abstract

A new method has been developed for the umpolung α-heteroarylation of ketones via an N-alkoxyenamine. The treatment of ketones with tris(heteroaryl)aluminum reagents in the presence of isoxazolidine gave the corresponding α-heteroarylated ketones in moderate to good yields.

Journal

• Chemical and Pharmaceutical Bulletin

  Chemical and Pharmaceutical Bulletin 62 (9), 927-932, 2014

  The Pharmaceutical Society of Japan

Keywords

• umpolung
• heteroarylation
• <i>N</i>-alkoxyenamine
• aluminum

Details

• CRID: 1390001204178338048
• NII Article ID: 130004684773
• NII Book ID: AA00602100
• DOI: 10.1248/cpb.c14-00404
• COI: 1:STN:280:DC%2BC2M%2FmvFKitA%3D%3D
• ISSN: 13475223
• ISSN: 00092363
• NDL BIB ID: 025737026
• PubMed: 25177020
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I025737026
• Web Site: https://www.jstage.jst.go.jp/article/cpb/62/9/62_c14-00404/_pdf
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed