Locomotor-Reducing Effects and Structural Characteristics of Inhaled Zerumbone and Tetrahydrozerumbone Derivatives

• Ogawa Kakuyou

  Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Kyoto University

• Miyoshi Takashi

  Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Kyoto University

• Kitayama Takashi

  Department of Advanced Bioscience, Graduate School of Agriculture, Kinki University

• Ito Michiho

  Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Kyoto University

抄録

Zerumbone 1 is an 11-membered cyclic sesquiterpene obtained from the rhizomes of Zingiber zerumbet SMITH (Zingiberaceae). In this study, we investigated the structure–activity relationship of 1, α-humulene (2), tetrahydrozerumbone stereoisomers (3–5), and tetrahydrozerumbone derivatives (6–9). The oxygen-containing functional groups and the configurations at C1 and C2 contributed to the spontaneous locomotor activity reduction of zerumbone 1 and derivatives 2–9.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 37 (9), 1559-1563, 2014

  公益社団法人 日本薬学会

キーワード

• zerumbone
• tetrahydrozerumbone
• sedative effect
• inhalation
• structure–activity relationship

詳細情報

• CRID: 1390282679610433280
• NII論文ID: 130004684793
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.b14-00314
• COI: 1:STN:280:DC%2BC2M%2FmvFKgtg%3D%3D
• ISSN: 13475215
• ISSN: 09186158
• HANDLE: 2433/190986
• NDL書誌ID: 025737081
• PubMed: 25177038
• Web Site: http://id.ndl.go.jp/bib/025737081
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I025737081
• Web Site: https://www.jstage.jst.go.jp/article/bpb/37/9/37_b14-00314/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2015190642
• 本文言語コード: en
• データソース種別:
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  • IRDB
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  • PubMed
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