Molecular Cloning and Gene Expression of Canine Apoptosis Inhibitor of Macrophage

• TOMURA Shintaro

  Laboratory of Veterinary Clinical Pathobiology, Department of Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan

• UCHIDA Mona

  Laboratory of Veterinary Clinical Pathobiology, Department of Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan

• YONEZAWA Tomohiro

  Laboratory of Veterinary Clinical Pathobiology, Department of Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan

• KOBAYASHI Masato

  Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University, 1–7–1 Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan

• BONKOBARA Makoto

  Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University, 1–7–1 Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan

• ARAI Satoko

  Laboratory of Molecular Biomedicine for Pathogenesis, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, 7–3–1 Hongo Bunkyo-ku, Tokyo 113-0033, Japan

• MIYAZAKI Toru

  Laboratory of Molecular Biomedicine for Pathogenesis, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, 7–3–1 Hongo Bunkyo-ku, Tokyo 113-0033, Japan CREST, Japan Science and Technology Agency, Hongo Bunkyo-ku, Tokyo 113-0033, Japan

• TAMAHARA Satoshi

  Laboratory of Veterinary Clinical Pathobiology, Department of Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan

• MATSUKI Naoaki

  Laboratory of Veterinary Clinical Pathobiology, Department of Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan

抄録

Apoptosis inhibitor of macrophage (AIM) plays roles in survival of macrophages. In this study, we cloned canine AIM cDNA and observed its transcriptional expression levels in various tissues. The coding sequence of canine AIM was 1,023 bp encoding 340 amino acid residues, which had around 65% homology with those of the human, mouse and rat. Transcriptional expression of AIM was observed in the spleen, lung, liver and lymph node, which confirmed the expression of canine AIM in tissue macrophages. Moreover, AIM was highly expressed in one of the canine histiocytic sarcoma cell lines. CD36, the receptor of AIM, was also expressed in various tissues and these cell lines. These findings are useful to reveal the actual functions of canine AIM.

収録刊行物

• Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ

  Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ 76 (12), 1641-1645, 2014

  公益社団法人 日本獣医学会

キーワード

• apoptosis inhibitor of macrophage (AIM)
• canine
• CD36
• CD5L
• scavenger receptor cysteine-rich (SRCR) superfamily

詳細情報

• CRID: 1390282681407849856
• NII論文ID: 130004684872
• DOI: 10.1292/jvms.14-0166
• ISSN: 13477439
• ISSN: 09167250
• Web Site: https://search.jamas.or.jp/link/ui/2015215811
• 本文言語コード: en
• データソース種別:
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  • CiNii Articles
  • KAKEN
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