Clinical Assessment of the Oral Malodor-reducing Effect of Oropharyngeal Lozenges

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  • Kosuke NAKANISHI
    Section of General Dentistry, Department of General Dentistry, Fukuoka Dental College
  • Nao SUZUKI
    Section of General Dentistry, Department of General Dentistry, Fukuoka Dental College
  • Masahiro YONEDA
    Section of General Dentistry, Department of General Dentistry, Fukuoka Dental College
  • Junichi YAMADA
    Section of General Dentistry, Department of General Dentistry, Fukuoka Dental College Fukuoka Tenjin Implant Clinic
  • Takao HIROFUJI
    Section of General Dentistry, Department of General Dentistry, Fukuoka Dental College

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Other Title
  • 口臭除去を効能とする口腔咽喉薬 (トローチ剤) の臨床的評価

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Abstract

 Purpose: Oral malodor results primarily from the microbial metabolism of amino acids in local debris in the oral cavity. This study compared the oral malodor-reducing effects of the following tablet or lozenge products: 1) Rose Wind, which contains cetylpiridinium chloride (CPC), dipotassium glycyrrhizate, and platycodon fluid extract (Shionogi); 2) Protect Drop, which contains CPC (Tokiwa Yakuhin); and 3) Frisk, a mint-flavored tablet (Kracie Holdings). Rinsing mouth with water was used as control.<br> Methods: The study was performed with 82 healthy student volunteers (mean age, 25.2±2.2 years). Of the participants, 57 who had oral malodor levels higher than 80 ppb as measured by a portable sulfide monitor were divided randomly into four groups: Rose Wind (n=15), Protect Drop (n=14), Frisk (n=14), and water-rinsed control (n=14). The oral malodor level, amount of salivary flow, salivary pH, salivary buffering capacity, and tongue moisture were examined before and after taking the products or rinsing with water.<br> Results: Each of the products reduced oral malodor significantly. In particular, both types of lozenges reduced oral maldor to less than 100 ppb, which is defined as no bad breath. Concerning the clinical parameters, salivary pH was significantly increased in the Rose Wind group, the buffering capacity of saliva was significantly increased in the Protect Drop group, and the amount of salivary flow was significantly increased in the Frisk group. The Rose Wind group showed an increasing tendency in tongue moisture, but this trend was not statistically significant.<br> Conclusion: Both of the lozenges tested showed excellent oral malodor-reducing effects. In addition, the three products examined in this study activated mouth functions.

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