Analysis of Acid Dissociation of Photo-degradable Haloperidol through the Measurement of Electrophoretic Mobility by Capillary Zone Electrophoresis

• SHIMAKAMI Natsumi

  Department of Chemical Science and Technology, Faculty of Engineering, The University of Tokushima

• YABUTANI Tomoki

  Department of Chemical Science and Technology, Faculty of Engineering, The University of Tokushima Institute of Technology and Science, The University of Tokushima

• TAKAYANAGI Toshio

  Department of Chemical Science and Technology, Faculty of Engineering, The University of Tokushima Institute of Technology and Science, The University of Tokushima

Bibliographic Information

Other Title

• キャピラリーゾーン電気泳動法を用いる電気泳動移動度の測定による光分解性ハロペリドールの酸解離反応解析
• キャピラリーゾーン デンキ エイドウホウ オ モチイル デンキ エイドウ イドウド ノ ソクテイ ニ ヨル ヒカリ ブンカイセイ ハロペリドール ノ サン カイリ ハンノウ カイセキ

Abstract

The acid dissociation constants (K_a) of Haloperidol and its degraded product were determined by capillary zone electrophoresis (CZE). Haloperidol is degraded by UV-light irradiation, and 4-(p-chlorophenyl)-4-hydroxypiperidine (CPHP) is generated from Haloperidol. When the irradiated solution was analyzed by CZE, residual Haloperidol and two degraded products were detected. The acid dissociation constant of Haloperidol was determined through the electrophoretic mobility of the residual Haloperidol, and the pK_a value determined was similar to that measured under no degradation conditions, as well as literature values. It was also confirmed that one of the degraded products was assigned to CPHP based on the migration time, the electrophoretic mobility, and its acid dissociation constant analyzed. It was demonstrated in this study that the acid dissociation constants are accurately determined by using CZE, even under degraded conditions of the analyte.

Journal

• BUNSEKI KAGAKU

  BUNSEKI KAGAKU 63 (8), 643-648, 2014

  The Japan Society for Analytical Chemistry

Keywords

• haloperidol
• 4-(<i>p</i>-chlorophenyl)-4-hydroxypiperidine
• capillary zone electrophoresis
• acid dissociation constant
• degradation

Details

• CRID: 1390282679637097856
• NII Article ID: 130004687300
• NII Book ID: AN00222633
• DOI: 10.2116/bunsekikagaku.63.643
• COI: 1:CAS:528:DC%2BC2cXhsVyrurvK
• NDL BIB ID: 025765476
• ISSN: 05251931
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I025765476
• Web Site: https://www.jstage.jst.go.jp/article/bunsekikagaku/63/8/63_643/_pdf
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed