Hepatosplenic Gamma-delta T-cell Lymphoma Associated with Epstein-Barr Virus

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Author(s)

    • Tsunematsu Seiji
    • Department of Gastroenterology and Hepatology, Hokkaido University, Graduate School of Medicine, Japan
    • Horimoto Hiromasa
    • Department of Gastroenterology and Hepatology, Hokkaido University, Graduate School of Medicine, Japan
    • Sho Takuya
    • Department of Gastroenterology and Hepatology, Hokkaido University, Graduate School of Medicine, Japan
    • Suda Goki
    • Department of Gastroenterology and Hepatology, Hokkaido University, Graduate School of Medicine, Japan
    • Nakanishi Mitsuru
    • Department of Gastroenterology and Hepatology, Hokkaido University, Graduate School of Medicine, Japan
    • Hashino Satoshi
    • Department of Gastroenterology and Hepatology, Hokkaido University, Graduate School of Medicine, Japan
    • Chuma Makoto
    • Department of Gastroenterology and Hepatology, Hokkaido University, Graduate School of Medicine, Japan
    • Sakamoto Naoya
    • Department of Gastroenterology and Hepatology, Hokkaido University, Graduate School of Medicine, Japan
    • Natsuizaka Mitsuteru
    • Department of Gastroenterology and Hepatology, Hokkaido University, Graduate School of Medicine, Japan
    • Fujita Hiromi
    • Department of Surgical Pathology, Hokkaido University Hospital, Japan
    • Otsuka Noriyuki
    • Department of Pathology, Hokkaido University, Graduate School of Medicine, Japan
    • Terashita Katsumi
    • Department of Gastroenterology and Hepatology, Hokkaido University, Graduate School of Medicine, Japan
    • Sato Fumiyuki
    • Department of Gastroenterology and Hepatology, Hokkaido University, Graduate School of Medicine, Japan
    • Kobayashi Tomoe
    • Department of Gastroenterology and Hepatology, Hokkaido University, Graduate School of Medicine, Japan
    • Nakai Masato
    • Department of Gastroenterology and Hepatology, Hokkaido University, Graduate School of Medicine, Japan
    • Tsukuda Yoko
    • Department of Gastroenterology and Hepatology, Hokkaido University, Graduate School of Medicine, Japan

Abstract

Hepatosplenic gamma-delta T-cell lymphoma (HSTCL) is a rare, aggressive subset of peripheral T-cell lymphoma. It has been reported that Epstein-Barr virus (EBV) infection can cause HSTCL; however, such cases are extremely rare, with only a few cases having been reported to date. We herein report an autopsy case of HSTCL associated with EBV infection. The presence of EBV infection was confirmed in serum EBV DNA and on <i>in-situ</i> hybridization, and cytotoxic molecules, such as granzyme B, perforin and T-cell intracytoplasmic antigen (TIA)-1, were all positive in lymphoma cells. These findings indicate that stimulation of persistent EBV infection may have caused HSTCL in this patient.<br>

Journal

  • Internal Medicine

    Internal Medicine 53(18), 2079-2082, 2014

    The Japanese Society of Internal Medicine

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