Analysis of Long-term Stored Plasma Samples for Investigation into the Pathophysiology of Vibration-induced White Finger: Preliminary Results

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  • KAWANO Yoshinao
    Department of Hygiene, Yamaguchi University Graduate School of Medicine, Japan
  • MAHBUB Hossain Md.
    Department of Hygiene, Yamaguchi University Graduate School of Medicine, Japan
  • HASE Ryosuke
    Department of Hygiene, Yamaguchi University Graduate School of Medicine, Japan
  • SAKAMOTO Tatsuo
    Department of Health and Sport Sciences, Chukyo University, Japan
  • HARADA Noriaki
    Department of Hygiene, Yamaguchi University Graduate School of Medicine, Japan

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Abstract

Blood samples were collected 25 yr ago from hand-arm vibration syndrome patients with vibration-induced white finge/VWF (VWF+ group) and without it (VWF− group), and healthy controls (n=12 in each group), and stored at −80°C. The subjects provided venous blood twice: at baseline, and after cold exposure at 7°C for 25 min. Blood specimens were analyzed for plasma endothelin-1 (ET-1) by an enzyme-linked immunosorbent assay. Baseline concentration of plasma ET-1 was found to be significantly larger in the VWF– group than the control group, whereas no such difference was observed for the VWF+ group. However, the %change was larger in the VWF+ group (107.73 ± 30.49%) than the other two groups, and more subjects in the VWF+ group showed the maximum increase in ET-1 than the other two groups. In conclusion, ET-1 appears to have a role in the pathophysiology of VWF.

Journal

  • Industrial Health

    Industrial Health 52 (6), 548-551, 2014

    National Institute of Occupational Safety and Health

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