Successful eculizumab treatment for multiple coronary thrombosis complicated in paroxysmal nocturnal hemoglobinuria
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- TANIGUCHI Ayuko
- Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University
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- IKEZOE Takayuki
- Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University
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- TAKEUCHI Asako
- Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University
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- TOGITANI Kazuto
- Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University
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- YOSHIMOTO Mitsuhiro
- Department of Medicine and Geriatrics, Kochi Medical School, Kochi University
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- TANIOKA Katsutoshi
- Department of Medicine and Geriatrics, Kochi Medical School, Kochi University
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- KITAOKA Hiroaki
- Department of Medicine and Geriatrics, Kochi Medical School, Kochi University
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- YOKOYAMA Akihito
- Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University
Bibliographic Information
- Other Title
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- 多発性冠動脈内血栓症を併発しエクリズマブが著効した発作性夜間ヘモグロビン尿症
- 症例報告 多発性冠動脈内血栓症を併発しエクリズマブが著効した発作性夜間ヘモグロビン尿症
- ショウレイ ホウコク タハツセイ カンドウミャク ナイ ケッセンショウ オ ヘイハツ シ エクリズマブ ガ チョコウシタ ホッサセイ ヤカン ヘモグロビン ニョウショウ
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Abstract
We herein report a rare case of paroxysmal nocturnal hemoglobinuria (PNH) who repeatedly developed coronary arterial thromboembolism. Anticoagulant therapies including heparin, aspirin as an antiplatelet agent and even drug-eluting stent placement in the coronary artery failed to prevent the recurrence of ischemic heart disease. Of note, initiating the administration of a humanized anti-C5 antibody, eculizumab, achieved prompt thrombolysis and maintenance treatment with eculizumab prevented the recurrence of thromboembolic disease in this patient. Taking these observations together, we suggest that the use of eculizumab be considered for treatment or prevention of arterial thrombosis complicated by PNH, although arterial thrombosis is an extremely rare event in the Japanese population.
Journal
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- Rinsho Ketsueki
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Rinsho Ketsueki 55 (8), 965-969, 2014
The Japanese Society of Hematology
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Details 詳細情報について
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- CRID
- 1390282680013168768
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- NII Article ID
- 130004688011
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- NII Book ID
- AN00252940
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- COI
- 1:STN:280:DC%2BC2M%2FotFCksw%3D%3D
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- ISSN
- 18820824
- 04851439
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- NDL BIB ID
- 025780917
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- PubMed
- 25186487
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed