Molecular dissection of <i>Mycobacterium tuberculosis</i>-containing phagosomes

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  • SETO Shintaro
    Department of Infectious Diseases, Hamamatsu University School of Medicine
  • NAGATA Toshi
    Department of Health Science, Hamamatsu University School of Medicine
  • HORII Toshinobu
    Department of Infectious Diseases, Hamamatsu University School of Medicine
  • KOIDE Yukio
    Executive Director and Vice-President, Hamamatsu University School of Medicine

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Other Title
  • 結核菌ファゴソームの分子解剖
  • ケッカクキン ファゴソーム ノ ブンシ カイボウ
  • Molecular dissection of Mycobacterium tuberculosis-containing phagosomes

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Abstract

Mycobacterium tuberculosis is an intracellular bacterium that can proliferate within phagocytosed macrophages. M. tuberculosis gains this ability by inhibiting phagolysosome biogenesis. On the other hand, autophagy induction can eliminate infected mycobacteria in macrophages. Numerous reports have demonstrated the mechanism of membrane trafficking in macrophages infected with mycobacteria to elucidate how M. tuberculosis proliferates within macrophages. In this review, we make a commentary on the molecular dissection of M. tuberculosis-containing phagosomes demonstrating which host factors constitute the replication niche for mycobacteria, and approach the real images of mycobacterial phagosomes.

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