Molecular dissection of <i>Mycobacterium tuberculosis</i>-containing phagosomes
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- SETO Shintaro
- Department of Infectious Diseases, Hamamatsu University School of Medicine
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- NAGATA Toshi
- Department of Health Science, Hamamatsu University School of Medicine
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- HORII Toshinobu
- Department of Infectious Diseases, Hamamatsu University School of Medicine
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- KOIDE Yukio
- Executive Director and Vice-President, Hamamatsu University School of Medicine
Bibliographic Information
- Other Title
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- 結核菌ファゴソームの分子解剖
- ケッカクキン ファゴソーム ノ ブンシ カイボウ
- Molecular dissection of Mycobacterium tuberculosis-containing phagosomes
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Abstract
Mycobacterium tuberculosis is an intracellular bacterium that can proliferate within phagocytosed macrophages. M. tuberculosis gains this ability by inhibiting phagolysosome biogenesis. On the other hand, autophagy induction can eliminate infected mycobacteria in macrophages. Numerous reports have demonstrated the mechanism of membrane trafficking in macrophages infected with mycobacteria to elucidate how M. tuberculosis proliferates within macrophages. In this review, we make a commentary on the molecular dissection of M. tuberculosis-containing phagosomes demonstrating which host factors constitute the replication niche for mycobacteria, and approach the real images of mycobacterial phagosomes.
Journal
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- Nippon Saikingaku Zasshi
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Nippon Saikingaku Zasshi 69 (3), 513-525, 2014
JAPANESE SOCIETY FOR BACTERIOLOGY
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Keywords
Details 詳細情報について
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- CRID
- 1390001206455872640
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- NII Article ID
- 130004688030
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- NII Book ID
- AN00189800
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- COI
- 1:STN:280:DC%2BC2M%2FotFGlsg%3D%3D
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- ISSN
- 18824110
- 00214930
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- NDL BIB ID
- 026233612
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- PubMed
- 25186642
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed