Formation of Isomerized <i>E</i>,<i>Z</i>-Configured 1,3-Dienes in Construction of Macrocyclic Trienes by Diene-Ene RCM
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Construction of macrocyclic trienes by diene-ene RCM of tetraenes was examined. In the reactions, macrocyclic trienes were obtained as a mixture of two isomers with <i>E</i>,<i>Z</i>-configured 1,3-diene moiety. The formation of two isomers can be understandable by the <i>E</i>–<i>Z</i> isomerization of the initially generated ruthenium–alkenyl carbene intermediate.
- Bulletin of the Chemical Society of Japan
Bulletin of the Chemical Society of Japan 88(1), 146-148, 2015
The Chemical Society of Japan