<i>S</i>-Mercuration of cellular proteins by methylmercury and its toxicological implications

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Author(s)

Abstract

The accumulation of methylmercury (MeHg) through the daily consumption of large predatory fish poses potential health risks. MeHg has been found to cause Minamata disease, but the full nature of MeHg toxicity remains unclear. Because of its chemical properties, MeHg covalently binds to cellular proteins through their reactive thiols, referred to as <i>S</i>-mercuration, resulting in the formation of protein adducts. In this review, we summarize how the<i> S</i>-mercuration of cellular proteins could be involved in the major mechanisms that have been suggested to underlie MeHg toxicity. Additionally, we introduce our attempts to identify cases of <i>S</i>-mercuration for the research to reveal the true nature of MeHg toxicity.

Journal

  • The Journal of Toxicological Sciences

    The Journal of Toxicological Sciences 39(5), 687-700, 2014

    The Japanese Society of Toxicology

Codes

  • NII Article ID (NAID)
    130004690955
  • NII NACSIS-CAT ID (NCID)
    AN00002808
  • Text Lang
    ENG
  • ISSN
    0388-1350
  • NDL Article ID
    025850759
  • NDL Call No.
    Z19-1022
  • Data Source
    NDL  J-STAGE 
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