Interferon Regulatory Factor 8 Expressed in Microglia Contributes to Tactile Allodynia Induced by Repeated Cold Stress in Rodents

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Author(s)

    • Matsumura Yuta Tsuda Makoto
    • Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan|Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan
    • Yasui Masaya [他] Kiyama Hiroshi
    • Department of Functional Anatomy and Neuroscience, Nagoya University Graduate School of Medicine, Japan|Core Research for Evolution Science and Technology, Japan Science and Technology Agency, Japan
    • Inoue Kazuhide
    • Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan|Core Research for Evolution Science and Technology, Japan Science and Technology Agency, Japan
    • Matsumura Yuta
    • Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan
    • Yasui Masaya
    • Department of Functional Anatomy and Neuroscience, Nagoya University Graduate School of Medicine, Japan|Core Research for Evolution Science and Technology, Japan Science and Technology Agency, Japan
    • Minami Emiko
    • Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan
    • Inoue Hidemasa
    • Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan
    • Masuda Takahiro
    • Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan|Core Research for Evolution Science and Technology, Japan Science and Technology Agency, Japan
    • Tozaki-Saitoh Hidetoshi
    • Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan
    • Tamura Tomohiko
    • Department of Immunology, Yokohama City University Graduate School of Medicine, Japan
    • Mizumura Kazue
    • Department of Physical Therapy, College of Life and Health Sciences, Chubu University, Japan

Abstract

We investigated the role of interferon regulatory factor 8 (IRF8) in a model of chronic pain in which repeated cold stress (RCS) exposure produces tactile allodynia. RCS exposure produced a decrease in paw withdrawal threshold (PWT) to mechanical stimulation. Spinal microglia of RCS-exposed mice were morphologically activated. Expression of IRF8 was significantly increased in the spinal cord of RCS-exposed mice and was localized in microglia. IRF8-knockout mice failed to show the RCS-induced decrease in PWT. Thus, RCS exposure activates spinal microglia and upregulation of IRF8 in these cells is involved in the development of tactile allodynia after RCS exposure.

Journal

  • Journal of Pharmacological Sciences

    Journal of Pharmacological Sciences 126(2), 172-176, 2014

    The Japanese Pharmacological Society

Codes

  • NII Article ID (NAID)
    130004693985
  • NII NACSIS-CAT ID (NCID)
    AA11806667
  • Text Lang
    ENG
  • ISSN
    1347-8613
  • NDL Article ID
    025861811
  • NDL Call No.
    Z53-D199
  • Data Source
    NDL  J-STAGE 
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