Interferon Regulatory Factor 8 Expressed in Microglia Contributes to Tactile Allodynia Induced by Repeated Cold Stress in Rodents

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  • Akagi Takanori
    Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan
  • Matsumura Yuta
    Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan
  • Yasui Masaya
    Department of Functional Anatomy and Neuroscience, Nagoya University Graduate School of Medicine, Japan Core Research for Evolution Science and Technology, Japan Science and Technology Agency, Japan
  • Minami Emiko
    Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan
  • Inoue Hidemasa
    Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan
  • Masuda Takahiro
    Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan Core Research for Evolution Science and Technology, Japan Science and Technology Agency, Japan
  • Tozaki-Saitoh Hidetoshi
    Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan
  • Tamura Tomohiko
    Department of Immunology, Yokohama City University Graduate School of Medicine, Japan
  • Mizumura Kazue
    Department of Physical Therapy, College of Life and Health Sciences, Chubu University, Japan
  • Tsuda Makoto
    Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan
  • Kiyama Hiroshi
    Department of Functional Anatomy and Neuroscience, Nagoya University Graduate School of Medicine, Japan Core Research for Evolution Science and Technology, Japan Science and Technology Agency, Japan
  • Inoue Kazuhide
    Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan Core Research for Evolution Science and Technology, Japan Science and Technology Agency, Japan

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We investigated the role of interferon regulatory factor 8 (IRF8) in a model of chronic pain in which repeated cold stress (RCS) exposure produces tactile allodynia. RCS exposure produced a decrease in paw withdrawal threshold (PWT) to mechanical stimulation. Spinal microglia of RCS-exposed mice were morphologically activated. Expression of IRF8 was significantly increased in the spinal cord of RCS-exposed mice and was localized in microglia. IRF8-knockout mice failed to show the RCS-induced decrease in PWT. Thus, RCS exposure activates spinal microglia and upregulation of IRF8 in these cells is involved in the development of tactile allodynia after RCS exposure.

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